NP_035243.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
urokinase plasminogen activator surface receptor
NCBI Official Synonym Full Names
plasminogen activator, urokinase receptor
NCBI Protein Information
urokinase plasminogen activator surface receptor; urokinase plasminogen activator receptor; urokinase-type plasminogen activator receptor
UniProt Protein Name
Urokinase plasminogen activator surface receptor
UniProt Synonym Gene Names
UniProt Entry Name
UPAR_MOUSE
UniProt Comments for PLAUR
uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, GPI anchor; Receptor, misc.; Motility/polarity/chemotaxis
Cellular Component: focal adhesion; membrane; integral to plasma membrane; plasma membrane; extracellular region
Molecular Function: protein domain specific binding; protein binding; enzyme binding; U-plasminogen activator receptor activity; receptor binding
Biological Process: mesenchymal cell differentiation; negative regulation of apoptosis
Research Articles on PLAUR
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Pathways associated with PLAUR protein
Diseases associated with PLAUR protein
Organs/Tissues associated with PLAUR protein
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