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PLCG1 recombinant protein :: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) Recombinant Protein

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Catalog # MBS955380
Unit / Price
Scan QR to view Datasheet
  0.5 mg (E-Coli)  /  $1,095 +1 FREE 8GB USB
  0.05 mg (Baculovirus)  /  $1,095 +1 FREE 8GB USB
  0.05 mg (Mammalian-Cell)  /  $1,325 +1 FREE 8GB USB
  0.5 mg (Yeast)  /  $1,325 +1 FREE 8GB USB
  1 mg (E-Coli)  /  $1,670 +2 FREE 8GB USB
  0.1 mg (Baculovirus)  /  $1,670 +2 FREE 8GB USB
  0.1 mg (Mammalian-Cell)  /  $2,130 +2 FREE 8GB USB
  1 mg (Yeast)  /  $2,130 +2 FREE 8GB USB
  0.5 mg (Baculovirus)  /  $2,165 +2 FREE 8GB USB
  1 mg (Baculovirus)  /  $3,295 +4 FREE 8GB USB
PLCG1 recombinant protein
Product Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1), Recombinant Protein

Popular Item
Full Product Name

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) , partial

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
550-851. Partial, include the SH2 domain and SH3 domain.
Sequence
WFHGKLGAGR DGRHIAERLL TEYCIETGAP DGSFLVRESE TFVGDYTLSF WRNGKVQHCR IHSRQDAGTP KFFLTDNLVF DSLYDLITHY QQVPLRCNEF EMRLSEPVPQ TNAHESKEWY HASLTRAQAE HMLMRVPRDG AFLVRKRNEP NSYAISFRAE GKIKHCRVQQ EGQTVMLGNS EFDSLVDLIS YYEKHPLYRK MKLRYPINEE ALEKIGTAEP DYGALYEGRN PGFYVEANPM PTFKCAVKAL FDYKAQREDE LTFIKSAIIQ NVEKQEGGWW RGDYGGKKQL WFPSNYVEEM VN
OMIM
172420
3D Structure
ModBase 3D Structure for P19174
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Human
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of PLCG1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PLCG1 recombinant protein
This protein catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
NCBI/Uniprot data below describe general gene information for PLCG1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
148,660 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform a
NCBI Official Synonym Full Names
phospholipase C gamma 1
NCBI Official Symbol
PLCG1  [Similar Products]
NCBI Official Synonym Symbols
PLC1; NCKAP3; PLC-II; PLC148; PLCgamma1
  [Similar Products]
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
UniProt Synonym Protein Names
PLC-148; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-II; PLC-II; Phospholipase C-gamma-1; PLC-gamma-1
UniProt Gene Name
PLCG1  [Similar Products]
UniProt Synonym Gene Names
PLC1; PLC-II; PLC-gamma-1  [Similar Products]
NCBI Summary for PLCG1
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for PLCG1
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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