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PMS1 cdna clone

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Catalog # MBS1274335
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  0.01 mg Plasmid + 0.2 mL Glycerol-Stock  /  $165 +1 FREE 8GB USB
PMS1 cdna clone
Product Name

PMS1, cDNA Clone

Popular Item
Full Product Name

PMS1 cDNA Clone

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGAAACAAT TGCCTGCGGC AACAGTTCGA CTCCTTTCAA GTTCTCAGAT CATCACTTCG GTGGTCAGTG TTGTAAAAGA GCTTATTGAA AACTCCTTGG ATGCTGGTGC CACAAGCGTA GATGTTAAAC TGGAGAACTA TGGATTTGAT AAAATTGAGG TGCGAGATAA CGGGGAGGGT ATCAAGGCTG TTGATGCACC TGTAATGGCA ATGAAGTACT ACACCTCAAA AATAAATAGT CATGAAGATC TTGAAAATTT GACAACTTAC GGTTTTCGTG GAGAAGCCTT GGGGTCAATT TGTTGTATAG CTGAGGTTTT AATTACAACA AGAACGGCTG CTGATAATTT TAGCACCCAG TATGTTTTAG ATGGCAGTGG CCACATACTT TCTCAGAAAC CTTCACATCT TGGTCAAGGT ACAACTGTAA CTGCTTTAAG ATTATTTAAG AATCTACCTG TAAGAAAGCA GTTTTACTCA ACTGCAAAAA AATGTAAAGA TGAAATAAAA AAGATCCAAG ATCTCCTCAT GAGCTTTGGT ATCCTTAAAC CTGACTTAAG GATTGTCTTT GTACATAACA AGGCAGTTAT TTGGCAGAAA AGCAGAGTAT CAGATCACAA GATGGCTCTC ATGTCAGTTC TGGGGACTGC TGTTATGAAC AATATGGAAT CCTTTCAGTA CCACTCTGAA GAATCTCAGA TTTATCTCAG TGGATTTCTT CCAAAGTGTG ATGCAGACCA CTCTTTCACT AGTCTTTCAA CACCAGAAAG AAGTTTCATC TTCATAAACA GTCGACCAGT ACATCAAAAA GATATCTTAA AGTTAATCCG ACATCATTAC AATCTGAAAT GCCTAAAGGA ATCTACTCGT TTGTATCCTG TTTTCTTTCT GAAAATCGAT GTTCCTACAG CTGATGTTGA TGTAAATTTA ACACCAGATA AAAGCCAAGT ATTATTACAA AATAAGGAAT CTGTTTTAAT TGCTCTTGAA AATCTGATGA CGACTTGTTA TGGACCATTA CCTAGTACAA ATTCTTATGA AAATAATAAA ACAGATGTTT CCGCAGCTGA CATCGTTCTT AGTAAAACAG CAGAAACAGA TGTGCTTTTT AATAAAGTGG AATCATCTGG AAAGAATTAT TCAAATGTTG ATACTTCAGT CATTCCATTC CAAAATGATA TGCATAATGA TGAATCTGGA AAAAACACTG ATGATTGTTT AAATCACCAG ATAAGTATTG GTGACTTTGG TTATGGTCAT TGTAGTAGTG AAATTTCTAA CATTGATAAA AACACTAAGA ATGCATTTCA GGACATTTCA ATGAGTAATG TATCATGGGA GAACTCTCAG ACGGAATATA GTAAAACTTG TTTTATAAGT TCCGTTAAGC ACACCCAGTC AGAAAATGGC AATAAAGACC ATATAGATGA GAGTGGGGAA AATGAGGAAG AAGCAGGTCT TGAAAACTCT TCGGAAATTT CTGCAGATGA GTGGAGCAGG GGAAATATAC TTAAAAATTC AGTGGGAGAG AATATTGAAC CTGTGAAAAT TTTAGTGCCT GAAAAAAGTT TACCATGTAA AGTAAGTAAT AATAATTATC CAATCCCTGA ACAAATGAAT CTTAATGAAG ATTCATGTAA CAAAAAATCA AATGTAATAG ATAATAAATC TGGAAAAGTT ACAGCTTATG ATTTACTTAG CAATCGAGTA ATCAAGAAAC CCATGTCAGC AAGTGCTCTT TTTGTTCAAG ATCATCGTCC TCAGTTTCTC ATAGAAAATC CTAAGACTAG TTTAGAGGAT GCAACACTAC AAATTGAAGA ACTGTGGAAG ACATTGAGTG AAGAGGAAAA ACTGAATCTT TTTAATGGAT CTCATTATTT AGACGTTTTA TATAAAATGA CAGCAGATGA CCAAAGATAC AGTGGATCAA CTTACCTGTC TGATCCTCGT CTTACAGCGA ATGGTTTCAA GATAAAATTG ATACCAGGAG TTTCAATTAC TGAAAATTAA
OMIM
600258
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of PMS1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for PMS1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62,919 Da
NCBI Official Full Name
Homo sapiens PMS1 postmeiotic segregation increased 1 (S. cerevisiae), mRNA
NCBI Official Synonym Full Names
PMS1 homolog 1, mismatch repair system component
NCBI Official Symbol
NCBI Official Synonym Symbols
MLH2; PMSL1; hPMS1; HNPCC3
  [Similar Products]
NCBI Protein Information
PMS1 protein homolog 1
UniProt Protein Name
PMS1 protein homolog 1
UniProt Synonym Protein Names
DNA mismatch repair protein PMS1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PMSL1  [Similar Products]
UniProt Entry Name
PMS1_HUMAN
NCBI Summary for PMS1
This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008]
UniProt Comments for PMS1
PMS1: Probably involved in the repair of mismatches in DNA. Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3 (HNPCC3). Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world, and accounts for 15% of all colon cancers. Cancers in HNPCC originate within benign neoplastic polyps termed adenomas. Clinically, HNPCC is often divided into two subgroups. Type I: hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II: patients have an increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected. Belongs to the DNA mismatch repair MutL/HexB family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor; DNA repair, damage

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: chiasma; MutLalpha complex; nucleus; synaptonemal complex

Molecular Function: ATPase activity; DNA binding; single-stranded DNA binding

Disease: Lynch Syndrome I
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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