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PNLIP protein :: Lipase Protein

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Catalog # MBS173153
Unit / Price
  100 Units  /  $260 +1 FREE 8GB USB
  500 Units  /  $620 +1 FREE 8GB USB
PNLIP protein
Product Name

Lipase (PNLIP), Protein

Popular Item
Also Known As

Lipase, Human Pancreas

Product Synonym Names
Pancreatic Triacylglycerol Lipase; PL; PTL; Pancreatic Lipase; Lipase, Human Pancreas - High Purity - Lyophilized
Product Gene Name
Product Synonym Gene Name
RP11-33D13.1; PL; PNLIPD; PTL[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS173153 COA
Sequence Length
398
OMIM
601980
3D Structure
ModBase 3D Structure for P16233
Purity/Purification
Purified
Form/Format
Lyophilized from tris chloride, pH 8.0, with sodium chloride, benzamidine and calcium chloride
Appearance: Tan powder
Source
Human Pancreas
EC Number
3.1.1.3
CAS Number
9001-62-1
Solubility
Clear, colorless (1 mg/mL saline)
Activity
100 units/vial (Dimension® Clinical Chemistry System)
Unit Definition
One unit will catalyze the hydrolysis of one micromole per minute of 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6┬ĺ-methylresorufin) ester in the presence of co-lipase, bile salt, and calcium chloride at 37 degree C.
Protein
0.03 mg protein/vial (Coomassie)
Specific Activity
3,000 units/mg protein (Coomassie)
Amylase
<0.01%
Protease
<0.01%
Ammonia
<0.01 micromole/vial
Declaration of Helsinki
All Donors provided signed Informed Consent in compliance with Declaration of Helsinki and filed with the appropriate agency/organization in the US.
Advice
Reconstitute with tris buffered saline containing 1% BSA and 1 mM calcium chloride.
Preparation and Storage
Aliquot and freeze at -20 degree C after reconstitution.
Handling: Handle as a potentially hazardous substance.
Storage Note: Protect from moisture
Shipping Note: Cold pack
Other Notes
Small volumes of PNLIP protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PNLIP protein
MyBioSource is the leading supplier of Human Pancreatic Lipase, for research and clinical diagnostic manufacturers.

Custom preparations, technical support, bulk quantities and aliquoting available.

Human Pancreatic lipase enzyme is a water-soluble enzyme that catalyzes the hydrolysis of ester bonds in water-insoluble, lipid substrates. Most lipases act at a specific position on the glycerol backbone of a lipid substrate (A1, A2 or A3).

Human pancreatic lipase clinical significance: Investigations of pancreatic disorders, pancreatitis, acute and chronic renal disease.
NCBI/Uniprot data below describe general gene information for PNLIP. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48 kDa
NCBI Official Full Name
lipase
NCBI Official Synonym Full Names
lipase, gastric
NCBI Official Symbol
NCBI Official Synonym Symbols
GL; HGL; HLAL
  [Similar Products]
NCBI Protein Information
gastric triacylglycerol lipase; gastric lipase
UniProt Protein Name
Gastric triacylglycerol lipase
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
GL; Gastric lipase  [Similar Products]
UniProt Entry Name
LIPG_HUMAN
NCBI Summary for PNLIP
This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
UniProt Comments for PNLIP
PNLIP: a member of the lipase gene family. It encodes a carboxyl esterase that hydrolyzes insoluble, emulsified triglycerides, and is essential for the efficient digestion of dietary fats. expressed specifically in the pancreas. [provided by RefSeq, Jul 2008]

Protein type: EC 3.1.1.3; Secreted, signal peptide; Secreted; Lipid Metabolism - glycerolipid; Hydrolase

Chromosomal Location of Human Ortholog: 10q26.1

Cellular Component: extracellular region

Molecular Function: triacylglycerol lipase activity; metal ion binding

Biological Process: phototransduction, visible light; cholesterol absorption; retinoid metabolic process; lipid digestion; lipid catabolic process

Disease: Pancreatic Lipase Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withPNLIP protein
 Reference Product  PubMed Publications
 LIPC protein  >1 publications with PNLIP and LIPC
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