NP_002677.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
phenylethanolamine N-methyltransferase
NCBI Official Synonym Full Names
phenylethanolamine N-methyltransferase
NCBI Protein Information
phenylethanolamine N-methyltransferase; phenylethanolamine N-methylase; noradrenaline N-methyltransferase
UniProt Protein Name
Phenylethanolamine N-methyltransferase
UniProt Synonym Protein Names
Noradrenaline N-methyltransferase
UniProt Synonym Gene Names
UniProt Entry Name
PNMT_HUMAN
NCBI Summary for PNMT
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for PNMT
PNMT: Converts noradrenaline to adrenaline. Belongs to the NNMT/PNMT/TEMT family.
Protein type: Amino Acid Metabolism - tyrosine; Methyltransferase; EC 2.1.1.28
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: cytosol
Molecular Function: phenylethanolamine N-methyltransferase activity
Biological Process: methylation; catecholamine biosynthetic process; epinephrine biosynthetic process
Disease: Hypertension, Essential
Research Articles on PNMT
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Products associated with PNMT recombinant protein
Pathways associated with PNMT recombinant protein
Diseases associated with PNMT recombinant protein
Organs/Tissues associated with PNMT recombinant protein
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