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PNMT recombinant protein :: Phenylethanolamine-N-Methyltransferase Recombinant Protein

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Catalog # MBS143536
Unit / Price
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  0.005 mg  /  $140 +1 FREE 8GB USB
  0.025 mg  /  $205 +1 FREE 8GB USB
  1 mg  /  $2,235 +2 FREE 8GB USB
PNMT recombinant protein
Product Name

Phenylethanolamine-N-Methyltransferase (PNMT), Recombinant Protein

Full Product Name

Recombinant Human Phenylethanolamine-N-Methyltransferase

Product Synonym Names
PNMT Human; Phenylethanolamine-N-Methyltransferase Human Recombinant; PENT; PNMTase; Noradrenaline-N-methyltransferase; Phenylethanolamine N-methyltransferase; PNMT; MGC34570
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MSGADRSPNA GAAPDSAPGQ AAVASAYQRF EPRAYLRNNY APPRGDLCNP NGVGPWKLRC LAQTFATGEV SGRTLIDIGS GPTVYQLLSA CSHFEDITMT DFLEVNRQEL GRWLQEEPGA FNWSMYSQHA CLIEGKGECW QDKERQLRAR VKRVLPIDVH QPQPLGAGSP APLPADALVS AFCLEAVSPD LASFQRALDH ITTLLRPGGH LLLIGALEES WYLAGEARLT VVPVSEEEVR EALVRSGYKV RDLRTYIMPA HLQTGVDDVK GVFFAWAQKV GL
OMIM
171190
3D Structure
ModBase 3D Structure for P11086
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The PNMT protein solution contains 20mM Tris-HCl, pH-8 & 10% Glycerol.
Sterile filtered colorless solution.
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of PNMT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PNMT recombinant protein
Description: Recombinant Human PNMT produced in E Coli is a single, non-glycosylated polypeptide chain containing 282 amino acids (1-282 a.a.) and having a molecular mass of 30.8 kDa.PNMT is purified by conventional chromatographic techniques.

Introduction: PNMT is an enzyme located in the adrenal medulla and it catalyzes the final step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). PNMT has beta-carboline 2N-methyltransferase activity. PNMT takes part in regulating epinephrine production. Glucocorticoid receptors form multimers of PNMT independent of the DNA binding domain. PNMT expression is regulated late in mouse gestation by AP2-alpha and glucocorticoids.
NCBI/Uniprot data below describe general gene information for PNMT. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Related Accession #
Molecular Weight
30,855 Da
NCBI Official Full Name
phenylethanolamine N-methyltransferase
NCBI Official Synonym Full Names
phenylethanolamine N-methyltransferase
NCBI Official Symbol
NCBI Official Synonym Symbols
PENT; PNMTase
  [Similar Products]
NCBI Protein Information
phenylethanolamine N-methyltransferase; noradrenaline N-methyltransferase; phenylethanolamine N-methylase
UniProt Protein Name
Phenylethanolamine N-methyltransferase
UniProt Synonym Protein Names
Noradrenaline N-methyltransferase
UniProt Gene Name
UniProt Synonym Gene Names
PENT; PNMTase  [Similar Products]
UniProt Entry Name
PNMT_HUMAN
NCBI Summary for PNMT
The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
UniProt Comments for PNMT
PNMT: Converts noradrenaline to adrenaline. Belongs to the NNMT/PNMT/TEMT family.

Protein type: Amino Acid Metabolism - tyrosine; Methyltransferase; EC 2.1.1.28

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: cytosol

Molecular Function: phenylethanolamine N-methyltransferase activity

Biological Process: methylation; catecholamine biosynthetic process; epinephrine biosynthetic process

Disease: Hypertension, Essential
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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