NP_033113.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
15,072 Da
NCBI Official Full Name
DNA-directed RNA polymerases I and III subunit RPAC2 isoform 1
NCBI Official Synonym Full Names
polymerase (RNA) I polypeptide D
NCBI Official Synonym Symbols
AC19; RPA16; Rpo1-3; 1110003G10Rik [Similar Products]
NCBI Protein Information
DNA-directed RNA polymerases I and III subunit RPAC2
UniProt Protein Name
DNA-directed RNA polymerases I and III subunit RPAC2
UniProt Synonym Protein Names
AC19; DNA-directed RNA polymerase I subunit D; RNA polymerase I 16 kDa subunit; RPA16
UniProt Synonym Gene Names
UniProt Entry Name
RPAC2_MOUSE
NCBI Summary for POLR1D
This gene encodes an RNA polymerase subunit that is a component of both the RNA polymerase I and RNA polymerase III complexes. RNA polymerase I is associated with transcription of pre-ribosomal RNAs, while RNA polymerase III is associated with transcription of small RNAs. Pseudogenes of this gene have been defined on chromosomes 4 and 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
UniProt Comments for POLR1D
POLR1D: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. Defects in POLR1D are the cause of Treacher Collins syndrome type 2 (TCS2). A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine
Cellular Component: DNA-directed RNA polymerase III complex; nucleus; DNA-directed RNA polymerase I complex
Molecular Function: protein dimerization activity; protein binding; DNA binding; DNA-directed RNA polymerase activity
Biological Process: transcription, DNA-dependent
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Products associated with POLR1D sirna
Pathways associated with POLR1D sirna
Diseases associated with POLR1D sirna
Organs/Tissues associated with POLR1D sirna
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