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anti-AREG antibody :: Rabbit AMPHIREGULIN Polyclonal Antibody

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Catalog # MBS220633
Unit / Price
  1 mL  /  $430 +1 FREE 8GB USB
anti-AREG antibody
Product Name

AMPHIREGULIN (AREG), Polyclonal Antibody

Popular Item
Also Known As

RABBIT ANTI HUMAN AMPHIREGULIN

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
252
OMIM
104640
3D Structure
ModBase 3D Structure for P15514
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 5.0 mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Buffer Solution
Phosphate buffered saline
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-AREG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AREG antibody
Rabbit anti Human Amphiregulin antibody recognizes human amphiregulin, an epidermal growth factor (EGF)-related glycoprotein that is involved in the differentiation and proliferation of a wide range of cell types. These actions are mediated through binding to the EGF receptor.The amino acid sequence of the peptide immunogen applies to the 252 amino acid precursor from the 'areg' gene. This contains sites that may be glycosylated in the native molecule.
Applications Tested/Suitable for anti-AREG antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for AREG. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,895 Da[Similar Products]
NCBI Official Full Name
amphiregulin preproprotein
NCBI Official Synonym Full Names
amphiregulin
NCBI Official Symbol
NCBI Official Synonym Symbols
AR; SDGF; AREGB; CRDGF
  [Similar Products]
NCBI Protein Information
amphiregulin; amphiregulin B; colorectum cell-derived growth factor; schwannoma-derived growth factor
UniProt Protein Name
Amphiregulin
UniProt Synonym Protein Names
Colorectum cell-derived growth factor; CRDGF
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
SDGF; AR; CRDGF  [Similar Products]
UniProt Entry Name
AREG_HUMAN
NCBI Summary for AREG
The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
UniProt Comments for AREG
AREG: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Belongs to the amphiregulin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane; nucleus

Molecular Function: protein binding; growth factor activity; cytokine activity; epidermal growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; response to peptide hormone stimulus; response to cAMP; response to glucocorticoid stimulus; response to estradiol stimulus; glial cell proliferation; G-protein coupled receptor protein signaling pathway; cell proliferation; cell-cell signaling; response to hydrogen peroxide; positive regulation of cell proliferation; negative regulation of osteoblast differentiation; positive regulation of DNA replication; neurite development; positive regulation of phosphorylation
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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