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anti-ASGR1 antibody :: Rabbit Asialoglycoprotein receptor 1 (ASGR1) Polyclonal Antibody

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Catalog # MBS286422
Unit / Price
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  0.1 mg  /  $245 +1 FREE 8GB USB
  0.5 mg  /  $620 +1 FREE 8GB USB
  1 mg  /  $850 +1 FREE 8GB USB
anti-ASGR1 antibody
Product Name

Asialoglycoprotein receptor 1 (ASGR1), Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti-human Asialoglycoprotein receptor 1 (ASGR1) Polyclonal antibody

Product Synonym Names
CLEC4H1; HL-1; ASGPR 1; Asialoglyco protein Receptor; C-type lectin domain family 4 member H1; Hepatic lectin H1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS286422 Technical Datasheet
OMIM
M10058 mRNA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Specificity
Reacts with: Mouse, Rat, Pig.
Purity/Purification
Rabbit Polyclonal IgG, affinity purified by Protein A.
Form/Format
Liquid
Concentration
1 mg/mL (lot specific)
Immunogen
KLH conjugated synthetic peptide derived from Human ASGR1.
Buffer
0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin 300 and 50% Glycerol.
Preparation and Storage
Storage: Shipped at 2-8°C, Store it under sterile conditions at -20°C to -80°C upon receiving. **Avoid repeated freeze-thaw cycles.**

Stability: Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-8°C.
Other Notes
Small volumes of anti-ASGR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASGR1 antibody
ASGR is a heterooligomeric receptor that is abundantly expressed on the sinusoidal surface of the hepatic plasma membrane. It is an endocytic receptor that rapidly binds and internalizes galactose-terminated glycoproteins (asialoglycoproteins or ASGP) from the circulation. The mouse ASGR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGR1 (MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The aa sequence of mouse ASGR1 ECD is 89% and 79% identical to the ASGR1 ECD of rat and human, respectively.
Applications Tested/Suitable for anti-ASGR1 antibody
SDS-PAGE; Western Blot (WB); ELISA (EIA)
Application Notes for anti-ASGR1 antibody
WB=1:500-2000
ELISA=1:500-1000
IHC-P=1:400-800
IHC-F=1:400-800
ICC=1:100-500
IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
NCBI/Uniprot data below describe general gene information for ASGR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted MW: 32 kDa
NCBI Official Full Name
Asialoglycoprotein receptor 1
NCBI Official Synonym Full Names
asialoglycoprotein receptor 1
NCBI Official Symbol
ASGR1  [Similar Products]
NCBI Official Synonym Symbols
HL-1; ASGPR; ASGPR1; CLEC4H1
  [Similar Products]
NCBI Protein Information
asialoglycoprotein receptor 1
UniProt Protein Name
Asialoglycoprotein receptor 1
UniProt Synonym Protein Names
C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1
UniProt Gene Name
ASGR1  [Similar Products]
UniProt Synonym Gene Names
CLEC4H1; ASGP-R 1; ASGPR 1; HL-1  [Similar Products]
NCBI Summary for ASGR1
This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for ASGR1
ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: integral to plasma membrane

Molecular Function: protein binding

Biological Process: receptor-mediated endocytosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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