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anti-APOH antibody :: Goat beta2-Glycoprotein-1 (APO-H) Polyclonal Antibody

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Catalog # MBS512023
Unit / Price
  5 mg  /  $310 +1 FREE 8GB USB
anti-APOH antibody
Product Name

beta2-Glycoprotein-1 (APO-H) (APOH), Polyclonal Antibody

Also Known As

Goat anti-human Apolipoprotein-H (beta2GPI), Whole IgG from antiserum

Product Synonym Names
beta2-Glycoprotein-1 (APO-H), human
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (64208147..64225556, complement). Location: 17q23-qter
OMIM
138700
3D Structure
ModBase 3D Structure for P02749
Clonality
Polyclonal
Host
Goat
Specificity
This antibody is specific for beta2GPI as demonstrated by immunoelectrophoresis and ELISA.
Purity/Purification
Purified IgG.
Vial containing ml of whole IgG representing approximately 1 ml of antiserum. Total protein is 5 mg.
Form/Format
Whole IgG, clear liquid.
Concentration
IgG concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 13.4. (lot specific)
Immunogen
Human beta2GPI purified from plasma.
Buffer
10 mM HEPES, pH 7.4, 150 mM NaCl, 50% (v/v) glycerol.
Neutralizing Activity
Not determined
Preparation and Storage
Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.
Other Notes
Small volumes of anti-APOH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-APOH antibody
Apolipoprotein-H, also known as beta2-Glycoprotein I (beta2GPI), is a plasma glycoprotein that circulates at a concentration of 200 ug/ml (4 uM). Synthesized in the liver, beta2GPI is a single chain molecule of 48 kDa, consisting of five repeating internally disulphide-bonded structures referred to as sushi domains. Relative to other glycoproteins, beta2GPI has an unusually high content of cysteine (6.2%), proline (8.3%) and carbohydrate (19%). Almost half the circulating beta2GPI in plasma is associated with lipoproteins of all major fractions. beta2GPI has been demonstrated to bind negatively charged phospholipids, heparin and platelets. Although the precise function(s) are as yet unknown, beta2GPI has been demonstrated to interfere with blood coagulation by competitively binding to negatively charged phospholipid surfaces exposed during cell activation or damage. Recent evidence also implicates beta2GPI as a cofactor recognized by anti-phospholipid antibodies present in some autoimmune disorders such as systemic lupus erythematosus (SLE)1-3.
Application Notes for anti-APOH antibody
Suitable as a source of antibodies to human beta2GPI.
NCBI/Uniprot data below describe general gene information for APOH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
38,298 Da[Similar Products]
NCBI Official Full Name
beta-2-glycoprotein 1
NCBI Official Synonym Full Names
apolipoprotein H (beta-2-glycoprotein I)
NCBI Official Symbol
NCBI Official Synonym Symbols
BG; B2G1; B2GP1
  [Similar Products]
NCBI Protein Information
beta-2-glycoprotein 1; B2GPI; apo-H; beta(2)GPI; APC inhibitor; anticardiolipin cofactor; activated protein C-binding protein
UniProt Protein Name
Beta-2-glycoprotein 1
UniProt Synonym Protein Names
APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
APOH_HUMAN
NCBI Summary for APOH
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq]
UniProt Comments for APOH
Function: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Subcellular location: Secreted.

Tissue specificity: Expressed by the liver and secreted in plasma.

Post-translational modification: N- and O-glycosylated. Ref.10 also reports glycosylation on 'Asn-188' for their allele. Ref.10 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19 Ref.20 Ref.21

Sequence similarities: Contains 4 Sushi (CCP/SCR) domains.
Product References and Citations for anti-APOH antibody
1. Lee, NS, Brewer HB Jr., Osborne JC Jr.; beta2Glycoprotein I: Molecular Properties of an Unusual Apolipoprotein, Apolipoprotein H; JBC 258, pp 4765-4770, 1983.
2. Schousboe I; beta2Glycoprotein I: A Plasma Inhibitor of the Contact Activation of the Intrinsic Blood Coagulation Pathway. Blood 66, pp 1 086-1091, 1985.
3. Nimpf J, Bevers EM, Bomans PHH, Till U, Wurm H, Kostner GM, Zwaal RFA; Prothrombinase activity of human platelets is inhibited by beta2Glycoprotein I; Biochimica et Biophysica Acta 884, pp 142-149, 1986.

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