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anti-CANX antibody :: Rabbit Calnexin Polyclonal Antibody

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Catalog # MBS194444
Unit / Price
  0.1 mL  /  $290 +1 FREE 8GB USB
anti-CANX antibody
Product Name

Calnexin (CANX), Polyclonal Antibody

Full Product Name

Calnexin

Product Synonym Names
Calnexin; Calnexin (NT)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_000005.9 (179125930..179158642). Location: 5q35
OMIM
114217
3D Structure
ModBase 3D Structure for P27824
Clonality
Polyclonal
Host
Rabbit
Specificity
Calnexin [Rabbit antibody recognizes calnexin of multiple species.]
This antibody recognizes human, mouse, rat, bovine, chicken, dog, guinea pig, hamster, pig, monkey, rabbit, and sheep calnexin.
Form/Format
100ul whole antiserum
Antigen
A 19 amino acid synthetic peptide corresponding to canine calnexin conjugated to KLH.
Preservatives
None.
Dilutions Instructions
Dilute in PBS or medium which is identical to that used in the assay system.
Preparation and Storage
This antibody is stable for at least one (1) year at -20 degree C. Avoid repeated freezing and thawing.
Other Notes
Small volumes of anti-CANX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CANX antibody
Calnexin is a ~90 kDa integral protein of the endoplasmic reticulum; it is also referred to as IP90, p88 and p90. It consists of a 50 kDa N-terminal calcium-binding luminal domain, a single transmembrane helix, and a short acidic cytoplasmic tail. Its positively charged cytosolic residues ensure its retention in the endoplasmic reticulum. Calnexin together with calreticulin play a key role in glycoprotein folding by interacting with folding intermediates via their monoglycosylated glycans. Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor, and B cell surface immuno-globulin.
Applications Tested/Suitable for anti-CANX antibody
Immunoblot
Application Notes for anti-CANX antibody
Immunoblotting: use at 1:5,000-1:10,000 dilution. A band of ~90 kDa is detected. These are recommended concentrations. User should determine optimal concentrations for their application.
Positive control: HeLa cell lysate.
NCBI/Uniprot data below describe general gene information for CANX. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
67,568 Da[Similar Products]
NCBI Official Full Name
calnexin
NCBI Official Synonym Full Names
calnexin
NCBI Official Symbol
NCBI Official Synonym Symbols
CNX; P90; IP90; FLJ26570
  [Similar Products]
NCBI Protein Information
calnexin; OTTHUMP00000161516; OTTHUMP00000223184; OTTHUMP00000223187; major histocompatibility complex class I antigen-binding protein p88
UniProt Protein Name
Calnexin
UniProt Synonym Protein Names
IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
Protein Family
UniProt Gene Name
UniProt Entry Name
CALX_HUMAN
NCBI Summary for CANX
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
UniProt Comments for CANX
Calnexin: a calcium-binding protein of the calreticulin family. A type I membrane protein of the endoplasmic reticulum .Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. May act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

Protein type: Endoplasmic reticulum; Calcium-binding; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: dendrite cytoplasm; endoplasmic reticulum membrane; smooth endoplasmic reticulum; protein complex; rough endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum; dendritic spine; cell soma; membrane; axon; melanosome; ribosome

Molecular Function: ionotropic glutamate receptor binding; protein binding; unfolded protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; carbohydrate binding

Biological Process: antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; protein folding; synaptic vesicle endocytosis; protein secretion; antigen processing and presentation of exogenous peptide antigen via MHC class II; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; aging
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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