NP_001001437.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,161 Da
NCBI Official Full Name
C-C motif chemokine 3-like 1
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 3-like 3
NCBI Official Synonym Symbols
LD78; 464.2; SCYA3L; G0S19-2; SCYA3L1; D17S1718; LD78BETA [Similar Products]
NCBI Protein Information
C-C motif chemokine 3-like 1; G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); chemokine (C-C motif) ligand 3-like, centromeric; small inducible cytokine A3-like 1; tonsillar lymphocyte LD78 beta protein
UniProt Protein Name
C-C motif chemokine 3-like 1
UniProt Synonym Protein Names
G0/G1 switch regulatory protein 19-2; LD78-beta(1-70); PAT 464.2; Small-inducible cytokine A3-like 1; Tonsillar lymphocyte LD78 beta proteinCleaved into the following 2 chains:LD78-beta(3-70); LD78-beta(5-70)
UniProt Synonym Gene Names
UniProt Entry Name
CL3L1_HUMAN
NCBI Summary for CCL3L1
This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]
UniProt Comments for CCL3L1
CCL3L1: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Chemokine; Secreted; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q21.1
Cellular Component: extracellular space; extracellular region
Molecular Function: chemokine activity
Biological Process: negative regulation of cell proliferation; immune response; inflammatory response
Disease: Human Immunodeficiency Virus Type 1, Susceptibility To
Research Articles on CCL3L1
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Pathways associated with anti-CCL3L1 antibody
Diseases associated with anti-CCL3L1 antibody
Organs/Tissues associated with anti-CCL3L1 antibody
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