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anti-CSNK2A1 antibody :: Rabbit CKII alpha Polyclonal Antibody

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Catalog # MBS194198
Unit / Price
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  0.1 mg  /  $460 +1 FREE 8GB USB
anti-CSNK2A1 antibody
Product Name

CKII alpha (CSNK2A1), Polyclonal Antibody

Full Product Name

CKII alpha Polyclonal Antibody

Product Synonym Names
CKII alpha; CKII alpha
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 20; NC_000020.10 (463338..524482, complement). Location: 20p13
OMIM
115440
3D Structure
ModBase 3D Structure for P68400
Clonality
Polyclonal
Host
Rabbit
Specificity
CKII alpha [Rabbit polyclonal antibody to CKII alpha]
This antibody reacts with human. Other species have not been tested. Antibody is affinity purified.
Form/Format
100 ug IgG in 0.1 ml Triscitrate/phosphate, pH 7-8
Antigen
Synthetic peptide representing a portion of the protein located within exons 12 and 13 (LocusLink ID 1457).
Stabilizer
None
Preservatives
0.1% Sodium Azide
Preparation and Storage
Store at 2 - 8 degree C. Antibody is stable at 2 - 8 degree C for 1 year.
Other Notes
Small volumes of anti-CSNK2A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CSNK2A1 antibody
Western Blot, Immunoprecipitation
Application Notes for anti-CSNK2A1 antibody
Western Blot: 0.3 - 1 ug/ml.
Immunoprecipitation: Use Catalog Number 13030.
NCBI/Uniprot data below describe general gene information for CSNK2A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
45,144 Da[Similar Products]
NCBI Official Full Name
casein kinase II subunit alpha isoform b
NCBI Official Synonym Full Names
casein kinase 2, alpha 1 polypeptide
NCBI Official Symbol
CSNK2A1  [Similar Products]
NCBI Official Synonym Symbols
CKII; CK2A1
  [Similar Products]
NCBI Protein Information
casein kinase II subunit alpha; CK II alpha; OTTHUMP00000029925; OTTHUMP00000029926; protein kinase CK2; CK2 catalytic subunit alpha; casein kinase II alpha 1 subunit
UniProt Protein Name
Casein kinase II subunit alpha
Protein Family
UniProt Gene Name
CSNK2A1  [Similar Products]
UniProt Synonym Gene Names
CK2A1  [Similar Products]
UniProt Entry Name
CSK21_HUMAN
NCBI Summary for CSNK2A1
Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq]
UniProt Comments for CSNK2A1
CK2A1: an ubiquitous protein kinase of the CK2 family. Exists as a tetramer composed of two catalytic subunits, alpha and alpha-prime, and two regulatory beta subunits. The beta subunits undergo autophosphorylation. The isoforms are rarely specified in publications. Two splice variant isoforms have been found. Participates in Wnt signaling. Phosphorylates E2 ubiquitin conjugating enzyme UBC3B inducing its interaction with beta-TRCp and enhancing beta-catenin degradation. May control IkB-alpha and p27Kip1 degradation. component of a CK2-SPT16-SSRP1 complex composed of SSRP1, PT16 CK2-A1, CK2-A2 and CK2-B the complex associating following UV irradiation. Interacts with RNPS1. Mouse transgene causes mammary gland hyperplasia and lymphoma, and activation by bovine parasites leads to fatal lymphoproliferation. Expression and activity are elevated in lung tumors and breast tumors. Antisense drives apoptosis of tumor cell lines and xenografts. Involved in DNA break repair by phosphorylation of scaffold protein XRCC1, phosphorylation of BRCA1, and phosphorylation of p53 in response to UV irradiation. Drosophila CK2 (Timekeeper) is involved in circadian regulation. Phosphorylates and binds to a major component of the inclusion bodies seen in Parkinson?s patients. Inhibitors: 4,5,6,7-tetrabromobenzotriazole (TBB).

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, Other; Other group; CK2 family

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: Sin3 complex; plasma membrane; NuRD complex; PcG protein complex; nucleus; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; protein N-terminus binding; Hsp90 protein binding; ATP binding

Biological Process: axon guidance; Wnt receptor signaling pathway; transcription, DNA-dependent; rhythmic process; negative regulation of caspase activity; signal transduction; positive regulation of cell growth; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of protein catabolic process; mitotic cell cycle; positive regulation of Wnt receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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