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anti-GZMM antibody :: Rabbit Granzyme M (GZMM) Polyclonal Antibody

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Catalog # MBS2017488 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $115 +1 FREE 8GB USB
  0.02 mg  /  $135 +1 FREE 8GB USB
  0.05 mg  /  $190 +1 FREE 8GB USB
  0.1 mg  /  $245 +1 FREE 8GB USB
  0.2 mg  /  $365 +1 FREE 8GB USB
  1 mg  /  $865 +1 FREE 8GB USB
Product Name

Granzyme M (GZMM), Polyclonal Antibody

Popular Item
Full Product Name

FITC-linked Antibody to Granzyme M (GZMM)

Matching Pairs
Unconjugated Antibody: Granzyme M (GZMM) (MBS2004112)
FITC Conjugated Antibody: Granzyme M (GZMM) (MBS2017488)
Matching Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-IIGGR EVIPHSRPYM ASLQRNGSHL CGGVLVHPKW VLTAAHCLAQ RMAQLRLVLG LHTLDSPGLT FHIKAAIQHP RYKPVPALEN DLALLQLDGK VKPSRTIRPL ALPSKRQVVA AGTRCSMAGW GLTHQGGRLS RVLRELDLQV LDTRMCNNSR FWNGSLSPSM VCLAADSKDQ APCKGDSGGP LVCGKGRVLA RVLSFSSRVC TDIFKPPVAT AVAPYVSWIR KVTGRSA
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Specificity
The antibody is a rabbit polyclonal antibody raised against GZMM. It has been selected for its ability to recognize GZMM in immunohistochemical staining and western blotting.
Purity/Purification
Affinity Chromatography.
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Concentration
100ug/mL (lot specific)
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-GZMM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-GZMM antibody
Applications Tested/Suitable for anti-GZMM antibody
Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-GZMM antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-GZMM antibody
(Figure. Western Blot; Sample: Recombinant protein.)
anti-GZMM antibody Western Blot (WB) (WB) image
Knockout Validation of anti-GZMM antibody
Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: GZMM knockout K562 cell lysate; Predicted MW: 28kd Observed MW: 25kd Primary Ab: 1ug/ml Rabbit Anti-Human GZMM Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047)
anti-GZMM antibody Knockout Validation image
NCBI/Uniprot data below describe general gene information for GZMM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI Accession #
NCBI Official Full Name
granzyme M
Protein Family
UniProt Comments for GZMM
GZMM: Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells. Belongs to the peptidase S1 family. Granzyme subfamily.

Protein type: Secreted, signal peptide; EC 3.4.21.-; Protease; Secreted

Cellular Component: membrane

Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity; endopeptidase activity

Biological Process: cell death; cytolysis; proteolysis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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