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Rabbit HIV1 protease Polyclonal Antibody

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Catalog # MBS536030
Unit / Price
  0.1 mg  /  $300 +1 FREE 8GB USB
anti-HIV1 protease antibody
Product Name

HIV1 protease, Polyclonal Antibody

Popular Item
Also Known As

HIV1 protease antibody

Product Synonym Names
Polyclonal HIV1 protease; Anti-HIV1 protease; HIV 1 protease; HIV-1 protease
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13285
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Binds to recombinant Protease (HIV -1). Not tested for sterility or endotoxin content.
Specificity
Human, Mouse, Rat; other species not tested. Please decide the specificity by homology.
Purity/Purification
> 95% pure
Form/Format
Supplied as a purified IgG in PBS buffer, >95% pure by SDS-PAGE analysis, with no preservatives added.
Concentration
1.0mg/ml (lot specific)
Biological Significance
HIV-1 protease (HIV PR) is a retroviral aspartyl protease that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV PR cleaves newly synthesized polyproteins at the appropriate places to create the mature protein components of an infectious HIV virion. Without effective HIV PR, HIV virions remain uninfectious. Thus, mutation of HIV PR?s active site or inhibition of its activity disrupts HIV?s ability to replicate and infect additional cells, making HIV PR inhibition the subject of much pharmaceutical research.
Immunogen
Full length recombinant Protease (HIV-1) expressed in E.coli Expression System
Preparation and Storage
Upon receipt store at -70 degree C
Shipping: Ships on dry ice.
Other Notes
Small volumes of anti-HIV1 protease antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HIV1 protease antibody
Rabbit polyclonal HIV1 protease antibody
Applications Tested/Suitable for anti-HIV1 protease antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-HIV1 protease antibody
If protein concentration is 1mg/ml, suggested starting dilutions are:
ELISA and Western Blot 1:500-1:1,000

Optimal dilutions must be determined by end user.
NCBI/Uniprot data below describe general gene information for HIV1 protease. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Comments for HIV1 protease
Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine (). Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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