• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-IgM antibody :: Sheep IgM Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS235397
Unit / Price
  1 mL  /  $285 +1 FREE 8GB USB
anti-IgM antibody
Product Name

IgM, Polyclonal Antibody

Popular Item
Also Known As

SHEEP ANTI HUMAN IgM

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
452
OMIM
147020
3D Structure
ModBase 3D Structure for P01871
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Specificity
This item recognises IgM. It does not exhibit cross-reactivity with albumin and human IgG. This antibody also has minimal cross reactivity with the following immunoglobulins.
Mouse IgG
Form/Format
Serum
Serum - liquid
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Immunogen
Human IgM isolated from pooled normal serum
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-IgM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IgM antibody
MBS235397 recognises IgM. It does not exhibit cross-reactivity with albumin and human IgG. This antibody also has minimal cross reactivity with the following immunoglobulins. Mouse IgG
Applications Tested/Suitable for anti-IgM antibody
ELISA (EIA), Immunodiffusion (ID), Immunoprecipitation (IP)
Application Notes for anti-IgM antibody
ELISA: Minimum Dilution: 1/50K; Maximum Dilution: 1/250K;
Immunodiffusion: Maximum Dilution: 1/32
NCBI/Uniprot data below describe general gene information for IgM. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,790 Da
NCBI Official Full Name
Ig mu chain C region, partial
NCBI Official Synonym Full Names
immunoglobulin heavy constant mu
NCBI Official Symbol
NCBI Official Synonym Symbols
MU; VH; AGM1
  [Similar Products]
UniProt Protein Name
Ig mu chain C region
Protein Family
UniProt Gene Name
UniProt Entry Name
IGHM_HUMAN
NCBI Summary for IgM
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]
UniProt Comments for IgM
IGHM: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as an homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. Defects in IGHM are the cause of agammaglobulinemia type 1 (AGM1). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane

Molecular Function: peptidoglycan binding; phosphatidylcholine binding; antigen binding; single-stranded DNA binding

Biological Process: adaptive immune response; antibacterial humoral response; innate immune response; defense response to Gram-negative bacterium

Disease: Agammaglobulinemia 1, Autosomal Recessive
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000