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anti-IL-1RA antibody :: Sheep Interleukin 1 Receptor Antagonist (IL-1RA) Polyclonal Antibody

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Catalog # MBS340186
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anti-IL-1RA antibody
Product Name

Interleukin 1 Receptor Antagonist (IL-1RA), Polyclonal Antibody

Full Product Name

Interleukin 1 Receptor Antagonist (IL-1RA)

Product Synonym Names
IL-1 Receptor Antagonist; IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 inhibitor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
147679
3D Structure
ModBase 3D Structure for P18510
Clonality
Polyclonal
Host
Sheep
Form/Format
Ig Fraction - Liquid
Concentration
>5mg/ml (U.V.abs @ 280nm) (lot specific)
Immunogen
Recombinant Human IL-1RA
Buffer
20mM Phosphate, 150mM Sodium Chloride
Preservative
0.09% Sodium Azide
Preparation and Storage
Upon delivery aliquot and store at -20 degree C. Avoid freeze / thaw cycles. Short term storage 2 - 8 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-IL-1RA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-IL-1RA antibody
IL-1Ra is the natural antagonist produced by a variety of cells including monocytes, macrophages, neutrophils and fibroblasts in response to the binding of various pro-inflammatory cytokines. Recombinant IL-1RA comprises a 152 amino acid fragment (26-177) corresponding to the mature soluble IL-1RA protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
Applications Tested/Suitable for anti-IL-1RA antibody
ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays
NCBI/Uniprot data below describe general gene information for IL-1RA. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,142 Da
NCBI Official Full Name
interleukin-1 receptor antagonist
NCBI Official Synonym Full Names
interleukin 1 receptor antagonist
NCBI Official Symbol
IL1RN  [Similar Products]
NCBI Official Synonym Symbols
DIRA; IRAP; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
  [Similar Products]
NCBI Protein Information
interleukin-1 receptor antagonist protein
UniProt Protein Name
Interleukin-1 receptor antagonist protein
UniProt Synonym Protein Names
ICIL-1RA; IL1 inhibitor; INN: Anakinra
UniProt Gene Name
IL1RN  [Similar Products]
UniProt Synonym Gene Names
IL1F3; IL1RA; IL-1RN; IL-1ra; IRAP  [Similar Products]
UniProt Entry Name
IL1RA_HUMAN
NCBI Summary for IL-1RA
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jan 2016]
UniProt Comments for IL-1RA
IL1RN: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. The intracellular form of IL1RN is predominantly expressed in epithelial cells. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: extracellular space; plasma membrane

Molecular Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 Type I receptor antagonist activity; interleukin-1 Type II receptor antagonist activity; interleukin-1, Type I receptor binding; interleukin-1, Type II receptor binding; protein binding

Biological Process: negative regulation of heterotypic cell-cell adhesion; response to glucocorticoid stimulus

Disease: Gastric Cancer, Hereditary Diffuse; Microvascular Complications Of Diabetes, Susceptibility To, 4; Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
Product References and Citations for anti-IL-1RA antibody
Dinarello, C.A. (1998) Int. Rev. Immunol. 16 (5-6): 457- 499.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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