WP_006248023.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
101,997 Da
NCBI Official Full Name
leukotoxin
NCBI Protein Information
leukotoxin
UniProt Protein Name
Leukotoxin
UniProt Synonym Gene Names
UniProt Entry Name
LKA1A_MANHA
UniProt Comments for lktA
Pasteurella leukotoxins are exotoxins that attack host leukocytes and especially polymorphonuclear cells, by causing cell rupture. The leukotoxin binds to the host LFA-1 integrin and induces a signaling cascade leading to many biological effects, including tyrosine phosphorylation of the CD18 tail, elevation of the intracellular Ca2+ and lysis of the host cell. This leukotoxin is a major contributor to the pathogenesis of lung injury in ovine pneumonic pasteurellosis. It has also week hemolytic activity.
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