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anti-MUC1 antibody :: Rabbit Mucin 1 (MUC1) Polyclonal Antibody

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Catalog # MBS2001934 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
Scan QR to view Datasheet
  0.01 mg  /  $100 +1 FREE 8GB USB
  0.02 mg  /  $110 +1 FREE 8GB USB
  0.05 mg  /  $150 +1 FREE 8GB USB
  0.1 mg  /  $195 +1 FREE 8GB USB
  0.2 mg  /  $270 +1 FREE 8GB USB
  1 mg  /  $645 +1 FREE 8GB USB
Product Name

Mucin 1 (MUC1), Polyclonal Antibody

Popular Item
Full Product Name

Polyclonal Antibody to Mucin 1 (MUC1)

Matching Pairs
Unconjugated Antibody: Mucin 1 (MUC1) (MBS2001934)
Biotin Conjugated Antibody: Mucin 1 (MUC1) (MBS2006267)
Matching Pairs
Matching Pairs
Unconjugated Antibody: Mucin 1 (MUC1) (MBS2001934)
FITC Conjugated Antibody: Mucin 1 (MUC1) (MBS2015301)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2001934 Technical Datasheet
OMIM
J05582 mRNA
3D Structure
ModBase 3D Structure for P15941
Clonality
Polyclonal
Host
Rabbit
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Concentration
0.47 mg/ml (lot specific)
Organism Species
Homo sapiens (Human)
Source
Polyclonal antibody preparation
Traits
Liquid
Immunogen
Recombinant MUC1 (Ser1098~Leu1255) expressed in E.coli
Preparation and Storage
Avoid repeated freeze/thaw cycles.
Store at 4ºC for frequent use.
Aliquot and store at -20ºC for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Other Notes
Small volumes of anti-MUC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MUC1 antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-MUC1 antibody
Western blotting: 0.5-2 ug/mL;1:230-940
Immunohistochemistry: 5-20 ug/mL;1:23-94
Immunocytochemistry: 5-20 ug/mL;1:23-94

Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-MUC1 antibody
Western Blot: Sample: Mouse Pancreas Tissue.
anti-MUC1 antibody Western Blot (WB) (WB) image
Western Blot (WB) of anti-MUC1 antibody
Western Blot: Sample: Recombinant MUC1, Human.
anti-MUC1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-MUC1 antibody
DAB staining on IHC-P; Samples: Human Kidney Tissue
anti-MUC1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-MUC1 antibody
DAB staining on IHC-P; Samples: Human Kidney Tissue)
anti-MUC1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for MUC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
mucin-1 isoform 2
NCBI Official Synonym Full Names
mucin 1, cell surface associated
NCBI Official Symbol
NCBI Official Synonym Symbols
EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC
  [Similar Products]
NCBI Protein Information
mucin-1
UniProt Protein Name
Mucin-1
UniProt Synonym Protein Names
Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta  [Similar Products]
NCBI Summary for MUC1
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
UniProt Comments for MUC1
MUC1: a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.

Protein type: Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: apical plasma membrane; extracellular exosome; extracellular space; Golgi lumen; integral component of plasma membrane; nuclear chromatin; plasma membrane; vesicle

Molecular Function: p53 binding; protein binding; transcription cofactor activity

Biological Process: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; negative regulation of cell adhesion mediated by integrin; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of transcription by competitive promoter binding; O-glycan processing; positive regulation of histone H4 acetylation; regulation of transcription from RNA polymerase II promoter in response to stress; stimulatory C-type lectin receptor signaling pathway

Disease: Medullary Cystic Kidney Disease 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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