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anti-NPR2 antibody :: Rabbit Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302) Polyclonal Antibody

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Catalog # MBS315495
Unit / Price
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  0.02 mL  /  $225 +1 FREE 8GB USB
anti-NPR2 antibody
Product Name

Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302) (NPR2), Polyclonal Antibody

Full Product Name

Rabbit anti Human NPR-B (a.a. 288-302)

Product Synonym Names
Rabbit Antibody to Human Natriuretic Peptide Receptor B (NPR-B) (amino acids 288-302)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 9; NC_000009.11 (35792406..35809728). Location: 9p21-p12
OMIM
108961
3D Structure
ModBase 3D Structure for P20594
Clonality
Polyclonal
Host
Rabbit
Specificity
Natriuretic Peptide Receptor B (NPR-B) (a.a. 288-302)
Synthetic human NPR-B peptide (a.a. 288-302)
Form/Format
Neat, Lyophilized.
Reconstitute in 20ul double distilled water.
Immunogen
Synthetic human NPR-B (a.a. 288-302) poly Lys. conjugated (QNRLLIRAREDFGVE)
Buffer
Not applicable
Preservative
No
Lyophilized
Yes
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Preparation and Storage
Store lyophilized product at 2 to 8 degree C. After reconstitution, store at -20 degree C. Avoid multiple freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-NPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-NPR2 antibody
Western Blot
NCBI/Uniprot data below describe general gene information for NPR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
117,022 Da[Similar Products]
NCBI Official Full Name
atrial natriuretic peptide receptor 2
NCBI Official Synonym Full Names
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
NCBI Official Symbol
NCBI Official Synonym Symbols
AMDM; ANPb; NPRB; ANPRB; GUC2B; NPRBi; GUCY2B
  [Similar Products]
NCBI Protein Information
atrial natriuretic peptide receptor 2; GC-B; ANP-B; NPR-B; ANPR-B; OTTHUMP00000021345; guanylate cyclase B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor type B
UniProt Protein Name
Atrial natriuretic peptide receptor 2
UniProt Synonym Protein Names
Atrial natriuretic peptide receptor type B; ANP-B; ANPR-B; NPR-B; Guanylate cyclase B
UniProt Gene Name
UniProt Synonym Gene Names
ANPRB  [Similar Products]
UniProt Entry Name
ANPRB_HUMAN
NCBI Summary for NPR2
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq]
UniProt Comments for NPR2
Function: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. Ref.9 Ref.11

Catalytic activity: GTP = 3',5'-cyclic GMP + diphosphate.

Subcellular location: Membrane; Single-pass type I membrane protein.

Post-translational modification: Phosphorylation of the protein kinase-like domain is required for full activation by CNP

Involvement in disease: Defects in NPR2 are the cause of acromesomelic dysplasia Maroteaux type (AMDM) [

MIM:602875]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDM is an autosomal recessive form characterized by axial skeletal involvement with wedging of vertebral bodies. In AMDM all skeletal elements are present but show abnormal rates of linear growth. Ref.11

Sequence similarities: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Contains 1 guanylate cyclase domain.Contains 1 protein kinase domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-NPR2 antibody
 Reference Product  PubMed Publications
 NPPC antibody  >5 publications with NPR2 and NPPC
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