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anti-PGE2 antibody :: Rabbit PGE2 Polyclonal Antibody

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Catalog # MBS480053
Unit / Price
  1 mL  /  $170 +1 FREE 8GB USB
Specificity Notes
Product Name

PGE2, Polyclonal Antibody

Popular Item
Also Known As

Anti-PGE2, Rabbit Polyclonal

Product Synonym Names
Anti-Prostaglandin E2
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
377
OMIM
608152
3D Structure
ModBase 3D Structure for Q9H7Z7
Clonality
Polyclonal
Host
Rabbit
Specificity
Not species specific. May not exhibit utility when using in a rabbit experimental model.
Purity/Purification
Not purified
Storage Buffer
PBS; 0.1% Sodium Azide
Sensitivity
130 pg/assay (IC50)
Immunogen
Prostaglandin E2
Preparation and Storage
At -80 degree C. AVOID REPEATED FREEZE THAWS.
Other Notes
Small volumes of anti-PGE2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PGE2 antibody
Description: This rabbit polyclonal antibody is specific to Prostaglandin E2 and other associated pathway specific arachidonate derived molecules. This antibody is presented as antiserum.
Applications Tested/Suitable for anti-PGE2 antibody
Radioimmunoassay (RIA), ELISA (EIA)
Application Notes for anti-PGE2 antibody
RIA: 1:25 dilution
May also have utility in ELISA.

Specificity Notes of anti-PGE2 antibody
anti-PGE2 antibody Specificity Notes image
NCBI/Uniprot data below describe general gene information for PGE2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
41,943 Da
NCBI Official Full Name
Prostaglandin E synthase 2
NCBI Official Synonym Full Names
prostaglandin E synthase 2
NCBI Official Symbol
PTGES2  [Similar Products]
NCBI Official Synonym Symbols
GBF1; GBF-1; PGES2; C9orf15; mPGES-2
  [Similar Products]
NCBI Protein Information
prostaglandin E synthase 2; GATE-binding factor 1; gamma-interferon-activated transcriptional element-binding factor 1; mPGE synthase-2; membrane-associated prostaglandin E synthase 2; membrane-associated prostaglandin E synthase-2; microsomal prostaglandin E synthase-2; prostaglandin-H(2) E-isomerase
UniProt Protein Name
Prostaglandin E synthase 2
UniProt Synonym Protein Names
Membrane-associated prostaglandin E synthase-2
UniProt Gene Name
PTGES2  [Similar Products]
UniProt Synonym Gene Names
C9orf15; PGES2; mPGES-2  [Similar Products]
UniProt Entry Name
PGES2_HUMAN
NCBI Summary for PGE2
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]
UniProt Comments for PGE2
PTGES2: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. Belongs to the GST superfamily.

Protein type: Isomerase; EC 5.3.99.3; Lipid Metabolism - arachidonic acid; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: Golgi membrane; mitochondrion; perinuclear region of cytoplasm; integral to membrane; cytosol; nucleus

Molecular Function: DNA binding; glutathione binding; electron carrier activity; lyase activity; heme binding; protein disulfide oxidoreductase activity; prostaglandin-E synthase activity

Biological Process: secretion; cell redox homeostasis; positive regulation of transcription, DNA-dependent; prostaglandin biosynthetic process
Product References and Citations for anti-PGE2 antibody
Levine, L., Measurement of Arachidonic Acid Metabolites by
Radioimmunoassay. In: Manual of Clinical Laboratory
Immunology (3rd Edition). J.L. Fahey, H. Friedman and N.L. Rose
(eds.). Amer. Soc. Microbiol. pp. 685-691 (1986).
Granstrom, E. and Lindgren, J.A., Radioimmunoassay of
Prostaglandins and Related Compounds. In: Prostaglandins:
Biology and Chemistry of Prostaglandins and Related
Eicosanoids, P.B. Curtis-Prior, (Ed.) Churchill Livingstone, New
York, pp. 115-12
6.
Powell, W.S., Rapid Extraction of Arachidonic Acid Metabolites From
Biological Samples Using Octadecylsilyl Silica. Meth. Enzymol.
86: 467-476 (1982).

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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