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anti-PRKCD antibody :: Rabbit PKC Delta Polyclonal Antibody

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Catalog # MBS352221
Unit / Price
  1 Bottle  /  $300 +1 FREE 8GB USB
anti-PRKCD antibody
Product Name

PKC Delta (PRKCD), Polyclonal Antibody

Also Known As

PKC Delta

Product Synonym Names
Protein Kinase C d (Human, Rat)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
676
Chromosome Location
Chromosome: 3; NC_000003.11 (53195223..53226733). Location: 3p21.31
OMIM
176977
3D Structure
ModBase 3D Structure for Q05655
Clonality
Polyclonal
Host
Rabbit
Other Notes
Small volumes of anti-PRKCD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-PRKCD antibody
Applications Tested/Suitable for anti-PRKCD antibody
Radioimmunoassay
NCBI/Uniprot data below describe general gene information for PRKCD. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
protein kinase C delta type
NCBI Official Synonym Full Names
protein kinase C, delta
NCBI Official Symbol
PRKCD  [Similar Products]
NCBI Official Synonym Symbols
MAY1; PKCD; MGC49908; nPKC-delta
  [Similar Products]
NCBI Protein Information
protein kinase C delta type; OTTHUMP00000165024; OTTHUMP00000165025; protein kinase C delta VIII
UniProt Protein Name
Protein kinase C delta type
UniProt Synonym Protein Names
nPKC-delta
Protein Family
UniProt Gene Name
PRKCD  [Similar Products]
UniProt Entry Name
KPCD_HUMAN
NCBI Summary for PRKCD
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]
UniProt Comments for PRKCD
Function: This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May play a role in antigen-dependent control of B-cell function. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. Ref.8

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Three specific sites; Thr-507 (activation loop of the kinase domain), Ser-645 (turn motif) and Ser-664 (hydrophobic region), need to be phosphorylated for its full activation.

Subunit structure: Interacts with PDK1, RAD9A, CDCP1 and MUC1. Ref.8 Ref.9 Ref.21

Subcellular location: Cytoplasm

By similarity. Membrane; Peripheral membrane protein

Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor.The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner.

Post-translational modification: Phosphorylated on Thr-507, within the activation loop. Autophosphorylated and/or phosphorylated. Although the Thr-507 phosphorylation occurs it is not a prerequisite for enzymatic activity

By similarity. Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18 Ref.19

Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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