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anti-PRKCH antibody :: Rabbit PKC Eta (Human) Polyclonal Antibody

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Catalog # MBS352230
Unit / Price
  1 Bottle  /  $300 +1 FREE 8GB USB
anti-PRKCH antibody
Product Name

PKC Eta (Human) (PRKCH), Polyclonal Antibody

Full Product Name

PKC Eta (Human)

Product Synonym Names
Protein Kinase C h (Human)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 14; NC_000014.8 (61788515..62017698). Location: 14q23.1
OMIM
601367
3D Structure
ModBase 3D Structure for P24723
Clonality
Polyclonal
Host
Rabbit
Other Notes
Small volumes of anti-PRKCH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-PRKCH antibody
Applications Tested/Suitable for anti-PRKCH antibody
Radioimmunoassay
NCBI/Uniprot data below describe general gene information for PRKCH. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
NCBI Official Full Name
protein kinase C eta type
NCBI Official Synonym Full Names
protein kinase C, eta
NCBI Official Symbol
PRKCH  [Similar Products]
NCBI Official Synonym Symbols
PKCL; PKC-L; PRKCL; MGC5363; MGC26269; nPKC-eta
  [Similar Products]
NCBI Protein Information
protein kinase C eta type; OTTHUMP00000179058
UniProt Protein Name
Protein kinase C eta type
UniProt Synonym Protein Names
PKC-L; nPKC-eta
Protein Family
UniProt Gene Name
PRKCH  [Similar Products]
UniProt Synonym Gene Names
PKCL; PRKCL  [Similar Products]
UniProt Entry Name
KPCL_HUMAN
NCBI Summary for PRKCH
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. [provided by RefSeq]
UniProt Comments for PRKCH
Function: This is calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Catalytic activity: ATP + a protein = ADP + a phosphoprotein.

Enzyme regulation: Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.

Subunit structure: Interacts with DGKQ. Ref.8

Tissue specificity: Most abundant in lung, less in heart and skin.

Domain: The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.

Involvement in disease: Defects in PRKCH may be a cause of susceptibility to ischemic stroke (ISCHSTR) [

MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Ref.13

Sequence similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 C2 domain.Contains 2 phorbol-ester/DAG-type zinc fingers.Contains 1 protein kinase domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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