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anti-RB1 antibody :: Rabbit Retinoblastoma phosphoserine 811 Polyclonal Antibody

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Catalog # MBS194346
Unit / Price
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  0.025 mg  /  $410 +1 FREE 8GB USB
anti-RB1 antibody
Product Name

Retinoblastoma phosphoserine 811 (RB1), Polyclonal Antibody

Full Product Name

Retinoblastoma (Rb) phosphoserine 811Polyclonal Antibody

Product Synonym Names
Retinoblastoma phosphoserine 811 polyclonal antibody
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 13; NC_000013.10 (48877883..49056026). Location: 13q14.2
OMIM
109800
3D Structure
ModBase 3D Structure for P06400
Clonality
Polyclonal
Host
Rabbit
Specificity
Retinoblastoma phosphoserine 811 polyclonal antibody [Rabbit polyclonal antibody specific for the phosphorylated form of human retinoblastoma protein at serine 811. Useful in WB. Available as affinity purified antibody.]
This antibody reacts with human Rb protein phosphorylated at serine 811. Mouse and rat (100% conserved) have not been tested.
Form/Format
Sequential immunoaffinity-purified antibody in phosphate buffer, pH 7.4
Antigen
Phosphopeptide region of human Rb containing serine 811
Positive Control
Jurkat cell lysate in high growth phase
Stabilizer
1 mg/ml BSA
Preservatives
0.05% Sodium Azide
Preparation and Storage
Store antibody at -80 degree C. Upon initial thawing, aliquot in appropriate aliquots and store at -80 degree C. Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of anti-RB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-RB1 antibody
Applications Tested/Suitable for anti-RB1 antibody
Western Blot
Application Notes for anti-RB1 antibody
Western Blotting: 0.50-1.5 ug/ml is recommended. The optimal antibody concentration should be determined for each specific application.
NCBI/Uniprot data below describe general gene information for RB1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
106,159 Da[Similar Products]
NCBI Official Full Name
retinoblastoma
NCBI Official Synonym Full Names
retinoblastoma 1
NCBI Official Symbol
NCBI Official Synonym Symbols
RB; pRb; OSRC; pp110; p105-Rb
  [Similar Products]
NCBI Protein Information
retinoblastoma-associated protein; OTTHUMP00000018397; retinoblastoma suspectibility protein
UniProt Protein Name
Retinoblastoma-associated protein
UniProt Synonym Protein Names
p105-Rb; pRb; Rb; pp110
UniProt Gene Name
UniProt Entry Name
RB_HUMAN
NCBI Summary for RB1
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq]
UniProt Comments for RB1
Rb: retinoblastoma tumor suppressor protein regulates cell proliferation by controlling progression through the G1-phase restriction point. Has three distinct binding domains and interacts with regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase and proteins with a conserved LXCXE motif. Cell cycle-dependent phosphorylation by Cdks inhibits Rb target binding, thus allowing cell cycle progression. Recruits and targets histone methyltransferase suv39h1 leading to epigenetic transcriptional repression.

Protein type: Oncoprotein; Nuclear receptor co-regulator; Tumor suppressor; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 13q14.2

Cellular Component: nucleoplasm; SWI/SNF complex; Rb-E2F complex; PML body; spindle; nucleus; chromatin

Molecular Function: identical protein binding; protein binding; androgen receptor binding; DNA binding; ubiquitin protein ligase binding; transcription coactivator activity; phosphoprotein binding; kinase binding; transcription factor binding; transcription factor activity

Biological Process: viral reproduction; sister chromatid biorientation; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter, mitotic; regulation of mitotic cell cycle; neuron maturation; cell cycle arrest; positive regulation of macrophage differentiation; neurite development; negative regulation of epithelial cell proliferation; transcription, DNA-dependent; negative regulation of transcription factor activity; mitotic cell cycle checkpoint; regulation of lipid kinase activity; enucleate erythrocyte differentiation; chromatin remodeling; myoblast differentiation; G1/S-specific transcription in mitotic cell cycle; neuron apoptosis; maintenance of mitotic sister chromatid cohesion; gut development; cell division; neuron morphogenesis during differentiation; negative regulation of smoothened signaling pathway; Ras protein signal transduction; androgen receptor signaling pathway; positive regulation of mitotic metaphase/anaphase transition; striated muscle cell differentiation; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; negative regulation of transcription, DNA-dependent; cell cycle checkpoint; G1/S transition of mitotic cell cycle

Disease: Bladder Cancer; Osteogenic Sarcoma; Small Cell Cancer Of The Lung; Retinoblastoma
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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