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anti-TAU antibody :: Goat TAU Polyclonal Antibody

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Catalog # MBS222468
Unit / Price
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  0.1 mL  /  $375 +1 FREE 8GB USB
anti-TAU antibody
Product Name

TAU, Polyclonal Antibody

Popular Item
Full Product Name

GOAT ANTI HUMAN TAU (aa1-16)

Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
157140
3D Structure
ModBase 3D Structure for P10636
Clonality
Polyclonal
Isotype
IgG
Host
Goat
Specificity
This item recognises tau, a 50 - 67 kD heterogeneous group of proteins that are involved in microtubule assembly. In healthy brain tissue tau is localised to the axons of neurons. Tau has also been associated with some neurological disease states including Alzheimer's disease.
Form/Format
Serum
Serum - liquid
Perservative Stabilisers
0.1% Sodium Azide
Immunogen
Synthetic peptide MAEPRQEFEVMEDHAG corresponding to amino acids 1-16 of human Tau.
Antiserum Preparation
Antisera to human Tau were raised by repeated immunisations of goats with highly purified antigen.
Target Species
Human
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-TAU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TAU antibody
MBS222468 recognises tau, a 50 - 67 kD heterogeneous group of proteins that are involved in microtubule assembly. In healthy brain tissue tau is localised to the axons of neurons. Tau has also been associated with some neurological disease states including Alzheimer's disease.
Applications Tested/Suitable for anti-TAU antibody
Immunohistology Paraffin*, Western Blot (WB)
Application Notes for anti-TAU antibody
Immunohistology - Paraffin: Minimum Dilution: 1/50; Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Maximum Dilution: 1/1000
NCBI/Uniprot data below describe general gene information for TAU. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
80,941 Da
NCBI Official Full Name
microtubule-associated protein tau isoform 6
NCBI Official Synonym Full Names
microtubule-associated protein tau
NCBI Official Symbol
NCBI Official Synonym Symbols
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
  [Similar Products]
NCBI Protein Information
microtubule-associated protein tau; G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; microtubule-associated protein tau, isoform 4; neurofibrillary tangle protein; paired helical filament-tau; protein phosphatase 1, regulatory subunit 103
UniProt Protein Name
Microtubule-associated protein tau
UniProt Synonym Protein Names
Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
MAPTL; MTBT1; TAU; PHF-tau  [Similar Products]
UniProt Entry Name
TAU_HUMAN
NCBI Summary for TAU
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
UniProt Comments for TAU
Tau: a microtubule-associated protein that regulates microtubule assembly and stability. Apparently involved in the establishment and maintenance of neuronal polarity. Mutations can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. Nine differentially spliced isoforms have been described. The short isoforms allow plasticity of the cytoskeleton, whereas the longer isoforms may preferentially play a role in its stabilization.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: microtubule; microtubule associated complex; growth cone; axon; tubulin complex; plasma membrane; axoneme; cytosol

Molecular Function: protein binding; enzyme binding; structural constituent of cytoskeleton; microtubule binding; apolipoprotein binding; protein kinase binding; SH3 domain binding

Biological Process: axon extension; apoptosis; positive regulation of microtubule polymerization; positive regulation of axon extension; axon cargo transport; neuron migration; microtubule cytoskeleton organization and biogenesis; regulation of microtubule polymerization; adult walking behavior; mitochondrion transport along microtubule; negative regulation of intracellular transport; generation of neurons; regulation of autophagy; cell structure disassembly during apoptosis

Disease: Supranuclear Palsy, Progressive, 1; Pick Disease Of Brain; Frontotemporal Dementia; Parkinson-dementia Syndrome; Parkinson Disease, Late-onset; Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-related
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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