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anti-TIMP1 antibody :: Rabbit Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) Polyclonal Antibody

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Catalog # MBS2004700 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
  0.01 mg  /  $100 +1 FREE 8GB USB
  0.02 mg  /  $110 +1 FREE 8GB USB
  0.05 mg  /  $145 +1 FREE 8GB USB
  0.1 mg  /  $185 +1 FREE 8GB USB
  0.2 mg  /  $255 +1 FREE 8GB USB
  1 mg  /  $595 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Tissue Inhibitors Of Metalloproteinase 1 (TIMP1), Polyclonal Antibody

Popular Item
Also Known As

Biotin-Linked Antibody to Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)

Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
MBS2004700 Technical Datasheet
Chromosome Location
Chromosome: X; NC_000023.10 (47441690..47446190). Location: Xp11.3-p11.23
OMIM
305370
3D Structure
ModBase 3D Structure for P01033
Clonality
Polyclonal
Host
Rabbit
Purity/Purification
Antigen-specific Affinity Chromatography
Form/Format
Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Concentration
0.45 mg/ml (lot specific)
Organism Species
Mus musculus (Mouse)
Source
Antibody labeling
Label
Biotin
Traits
Liquid
Immunogen
Recombinant TIMP1 (Ala35~Pro160) expressed in E.coli.
Preparation and Storage
Storage: Avoid repeated freeze/thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Other Notes
Small volumes of anti-TIMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-TIMP1 antibody
Applications Tested/Suitable for anti-TIMP1 antibody
WB; IHC; ICC; IP.
Application Notes for anti-TIMP1 antibody
Western blotting: 0.5-2)Ug/mL;1:220-900
Immunohistochemistry: 5-20)Ug/mL;1:22-90
Immunocytochemistry: 5-20)Ug/mL;1:22-90

Optimal working dilutions must be determined by end user.

Western Blot (WB) of anti-TIMP1 antibody
(Figure. Western Blot; Sample: Recombinant protein.)
anti-TIMP1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TIMP1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
tissue inhibitor of metalloproteinase 1, partial
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 1
NCBI Official Symbol
TIMP1  [Similar Products]
NCBI Official Synonym Symbols
EPA; EPO; HCI; CLGI; TIMP
  [Similar Products]
NCBI Protein Information
metalloproteinase inhibitor 1; TIMP-1; collagenase inhibitor; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; tissue inhibitor of metalloproteinases 1
UniProt Protein Name
Metalloproteinase inhibitor 1
UniProt Synonym Protein Names
Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1
UniProt Gene Name
TIMP1  [Similar Products]
UniProt Synonym Gene Names
CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1  [Similar Products]
UniProt Entry Name
TIMP1_HUMAN
NCBI Summary for TIMP1
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
UniProt Comments for TIMP1
TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: Xp11.3-p11.23

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region; basement membrane

Molecular Function: metalloendopeptidase inhibitor activity; protein binding; growth factor activity; protease binding; metal ion binding; cytokine activity

Biological Process: response to peptide hormone stimulus; platelet activation; negative regulation of metalloenzyme activity; extracellular matrix organization and biogenesis; response to hormone stimulus; negative regulation of membrane protein ectodomain proteolysis; extracellular matrix disassembly; platelet degranulation; response to cytokine stimulus; positive regulation of cell proliferation; blood coagulation; aging; negative regulation of apoptosis
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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