NP_001001331.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
134,040 Da
NCBI Official Full Name
plasma membrane calcium-transporting ATPase 2 isoform 1
NCBI Official Synonym Full Names
ATPase, Ca++ transporting, plasma membrane 2
NCBI Protein Information
plasma membrane calcium-transporting ATPase 2; plasma membrane Ca2+ pump 2; plasma membrane calcium pump; plasma membrane Ca(2+)-ATPase; plasma membrane calcium ATPase
UniProt Protein Name
Plasma membrane calcium-transporting ATPase 2
UniProt Synonym Protein Names
Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2
UniProt Synonym Gene Names
UniProt Entry Name
AT2B2_HUMAN
NCBI Summary for ATP2B2
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP2B2
ATP2B2: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. 8 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.3.8; Transporter, ion channel; Hydrolase; Transporter; Cell development/differentiation; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3p25.3
Cellular Component: cell soma; endoplasmic reticulum; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; synapse; cell junction; cilium
Molecular Function: protein C-terminus binding; calmodulin binding; protein binding; calcium-transporting ATPase activity; metal ion binding; calcium ion binding; calcium-dependent ATPase activity; ATP binding; PDZ domain binding
Biological Process: lactation; cytosolic calcium ion homeostasis; organelle organization and biogenesis; otolith mineralization; regulation of synaptic plasticity; locomotory behavior; detection of mechanical stimulus involved in sensory perception of sound; cerebellar granule cell differentiation; neuron differentiation; sensory perception of sound; transport; calcium ion transport; cerebellar Purkinje cell differentiation; synapse organization and biogenesis; auditory receptor cell stereocilium organization and biogenesis; positive regulation of calcium ion transport; locomotion; neuromuscular process controlling balance; blood coagulation; regulation of cell size; cGMP metabolic process; transmembrane transport; serotonin metabolic process
Disease: Deafness, Autosomal Recessive 12
Research Articles on ATP2B2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-ATP2B2 antibody
Diseases associated with anti-ATP2B2 antibody
Organs/Tissues associated with anti-ATP2B2 antibody
|