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anti-LYZ antibody :: Rabbit LYZ / Lysozyme Polyclonal Antibody

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Catalog # MBS246897
Unit / Price
  0.25 mL  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

LYZ / Lysozyme, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit Polyclonal (IgG) to Human LYZ / Lysozyme

Product Synonym Names
Anti-LYZ / Lysozyme Antibody IHC-plus; LYZ; 1;4-beta-N-acetylmuramidase C; LZM; Lysozyme; Lysozyme (renal amyloidosis); Renal amyloidosis; Lysozyme C; Human LYZ; Lysozyme
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
phenotype 153450
3D Structure
ModBase 3D Structure for P61626
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Baboon, Cat, Dog, Human, Monkey, Pig
Purity/Purification
Purified
Form/Format
10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
Target Species
Human
Non Reactive Species
Mouse, Rat
Immunogen Description
Human lysozyme purified from the urine of patients with monocytic leukemia.
Immunogen Species
LYZ/Lysozyme antibody was raised against Human.
Immunogen
LYZ / Lysozyme antibody was raised against human lysozyme purified from the urine of patients with monocytic leukemia.
POSITIVE CONTROL
Tonsil, colon, or skin.
CELLULAR LOCALIZATION
Cytoplasmic
Preparation and Storage
+4 degree C, avoid freezing
Other Notes
Small volumes of anti-LYZ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-LYZ antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-LYZ antibody
IHC-P (1:100)

Immunohistochemistry (IHC) of anti-LYZ antibody
Anti-Lysozyme antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
anti-LYZ antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for LYZ. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
16,537 Da
NCBI Official Full Name
lysozyme C
NCBI Official Synonym Full Names
lysozyme
NCBI Official Symbol
NCBI Official Synonym Symbols
NCBI Protein Information
lysozyme C; c-type lysozyme; 1,4-beta-N-acetylmuramidase C
UniProt Protein Name
Lysozyme C
UniProt Synonym Protein Names
1,4-beta-N-acetylmuramidase C
UniProt Gene Name
UniProt Synonym Gene Names
UniProt Entry Name
LYSC_HUMAN
NCBI Summary for LYZ
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Missense mutations in this gene have been identified in heritable renal amyloidosis. [provided by RefSeq, Oct 2014]
UniProt Comments for LYZ
LYZ: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents. Defects in LYZ are a cause of amyloidosis type 8 (AMYL8); also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. Belongs to the glycosyl hydrolase 22 family.

Protein type: Hydrolase; Secreted; EC 3.2.1.17; Endoplasmic reticulum; Vesicle; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: extracellular space; extracellular region

Molecular Function: identical protein binding; lysozyme activity

Biological Process: retinal homeostasis; metabolic process; cytolysis; defense response to bacterium; inflammatory response

Disease: Amyloidosis, Familial Visceral
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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