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anti-S100A6 antibody :: Rabbit S100 Calcium Binding Protein A6 Polyclonal Antibody

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Catalog # MBS617365
Unit / Price
  0.25 mL  /  $505 +1 FREE 8GB USB
anti-S100A6 antibody
Product Name

S100 Calcium Binding Protein A6 (S100A6), Polyclonal Antibody

Also Known As

S100 Calcium Binding Protein A6 (Calcyclin, Prolactin Receptor Associated Protein)

Product Synonym Names
Anti -S100 Calcium Binding Protein A6 (Calcyclin, Prolactin Receptor Associated Protein)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (153507076..153508717, complement). Location: 1q21
OMIM
114110
3D Structure
ModBase 3D Structure for P06703
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Canine, Equine, Feline, Human, Mouse, Rat
Specificity
Recognizes human S100A6. Species Crossreactivity: Mouse, Rat, Bovine, Equine, Feline and Canine.
Purity/Purification
Serum
Serum.
Form/Format
Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA and 0.09% sodium azide.
Immunogen
Purified recombinant human S100A6 monomer expressed in E. coli. Cellular Localization: Cytoplasmic.
Positive Control
Tonsil
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-S100A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-S100A6 antibody
S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein is also expressed in the antigen presenting cells such as the Langerhans cells in skin and interdigitating reticulum cells in the paracortex of lymph nodes.
Applications Tested/Suitable for anti-S100A6 antibody
Immunohistochemistry (IHC)
Application Notes for anti-S100A6 antibody
Suitable for use in Immunohistochemistry.
Dilution: Immunohistology (Formalin/paraffin): 1:50-1:100 for 30min at RT. Staining of formalin-fixed tissues REQUIRES boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Optimal dilutions to be determined by the researcher.
NCBI/Uniprot data below describe general gene information for S100A6. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,180 Da[Similar Products]
NCBI Official Full Name
S100 calcium binding protein A6
NCBI Official Synonym Full Names
S100 calcium binding protein A6
NCBI Official Symbol
S100A6  [Similar Products]
NCBI Official Synonym Symbols
2A9; PRA; 5B10; CABP; CACY
  [Similar Products]
NCBI Protein Information
protein S100-A6; MLN 4; calcyclin; OTTHUMP00000015472; growth factor-inducible protein 2A9; prolactin receptor-associated protein; S100 calcium-binding protein A6 (calcyclin)
UniProt Protein Name
Protein S100-A6
UniProt Synonym Protein Names
Calcyclin; Growth factor-inducible protein 2A9; MLN 4; Prolactin receptor-associated protein; PRA; S100 calcium-binding protein A6
Protein Family
UniProt Gene Name
S100A6  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
S10A6_HUMAN
NCBI Summary for S100A6
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma. [provided by RefSeq]
UniProt Comments for S100A6
S100A6: May function as calcium sensor and contribute to cellular calcium signaling (Potential). May function by interacting with other proteins and indirectly play a role in the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative. Belongs to the S-100 family.

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: ruffle; extrinsic to internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; nuclear envelope; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; zinc ion binding; ion transmembrane transporter activity; calcium ion binding; tropomyosin binding; calcium-dependent protein binding

Biological Process: positive regulation of fibroblast proliferation; axonogenesis; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-S100A6 antibody
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