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anti-hspa1l antibody :: Rabbit Heat Shock Cognate Protein 70 Polyclonal Antibody

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Catalog # MBS610216
Unit / Price
  0.05 mg  /  $420 +1 FREE 8GB USB
  0.2 mg  /  $680 +1 FREE 8GB USB
anti-hspa1l antibody
Product Name

Heat Shock Cognate Protein 70 (hspa1l), Polyclonal Antibody

Full Product Name

Heat Shock Cognate Protein 70 (HSC70, HSP73)

Product Synonym Names
Anti -Heat Shock Cognate Protein 70 (HSC70, HSP73)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Bovine, Canine, Guinea Pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
Specificity
Recognizes human Hsc70 at ~73kD. Species Crossreactivity: mouse, rat, bovine, canine, guinea pig, hamster, monkey, porcine, rabbit and sheep.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, 50% glycerol.
Immunogen
A 13 residue synthetic peptide based on the human Hsc70 (residues 556-568). The peptide antibody was produced using MAP (ìmulitiple antigenic peptideî) resin technology.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-hspa1l antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-hspa1l antibody
The 70 kD heat shock cognate protein, Hsc70 is closely related biochemically and biologically to Hsp70 and is part of the Hsp70 family which contains a number of highly-related protein isoforms ranging in size from 66kD to 78kD. These proteins include both cognate members which are found within major intracellular compartments and highly inducible isoforms which appear to be predominantly cytoplasmic or nuclear in distribution (1). Members of the Hsp70 family are molecular chaperones which are involved in many cellular functions such as protein folding, transport, maturation and degradation and they exert their function in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains as well as partially folded intermediates of proteins preventing their aggregation and misfolding and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein (2). Recent data has demonstrated that BAG-1 which possesses a ubiquitin-like domain at its amino terminus modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal a role of BAG-1 as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome (3). There is also experimental data which shows that the ATPase domain and the substrate binding domain of Hsc70 cooperate and form a cochaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp) which is essential for normal neurotransmitter release (4).
Applications Tested/Suitable for anti-hspa1l antibody
Western Blot (WB)
Application Notes for anti-hspa1l antibody
Dilution: Western Blot (Colorimetric): 1:1000
Optimal dilutions to be determined by researcher.

Positive Controls:
Recombinant Bovine Hsc70 Protein and HeLa Cell Lysate
NCBI/Uniprot data below describe general gene information for hspa1l. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
heat shock 70kDa protein 1-like
NCBI Official Synonym Full Names
heat shock 70kDa protein 1-like
NCBI Official Symbol
hspa1l  [Similar Products]
NCBI Official Synonym Symbols
hsc70; hsc70.I; MGC52655
  [Similar Products]
NCBI Protein Information
heat shock 70kDa protein 1-like; heat shock cognate protein 70
Protein Family
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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