NP_001015001.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
creatine kinase U-type, mitochondrial isoform 1
NCBI Official Synonym Full Names
creatine kinase, mitochondrial 1A
NCBI Protein Information
creatine kinase U-type, mitochondrial
UniProt Protein Name
Creatine kinase U-type, mitochondrial
UniProt Synonym Protein Names
Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK
UniProt Synonym Gene Names
NCBI Summary for CKMT1A
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for CKMT1A
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.
Research Articles on CKMT1A
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Products associated with anti-CKMT1A antibody
Pathways associated with anti-CKMT1A antibody
Diseases associated with anti-CKMT1A antibody
Organs/Tissues associated with anti-CKMT1A antibody
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