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anti-DES antibody :: Goat DES / Desmin Polyclonal Antibody

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Catalog # MBS243304
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

DES / Desmin, Polyclonal Antibody

Also Known As

Goat Polyclonal to Human DES / Desmin

Product Synonym Names
Anti-DES / Desmin Antibody (C-Terminus) IHC-plus; DES; ARVC7; ARVD7; CMD1I; CSM1; CSM2; MFM1; SCPNK; Desmin; Intermediate filament protein; Human DES; Desmin
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
470
OMIM
phenotype 615325
3D Structure
ModBase 3D Structure for P17661
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Specificity
Human DES / Desmin.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide C-RDGEVVSEATQQQHE from the C-terminus of human DES / Desmin (NP_001918.3).
Immunogen Type
Synthetic peptide
Immunogen
DES / Desmin antibody was raised against synthetic peptide C-RDGEVVSEATQQQHE from the C-terminus of human DES / Desmin (NP_001918.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Shrew, Hamster, Elephant, Panda, Bat, Bovine, Dog, Rabbit, Horse, Pig, Opossum, Turkey, Chicken, Armadillo (100%); Lizard (93%); Xenopus (80%).
Antigen Modification
C-Terminus
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-DES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DES antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-DES antibody
ELISA (1:2000), IHC-P (3.75 ug/ml), WB (0.1 - 0.3 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:2000. Western Blot: Approx. 55kD band observed in Human Skeletal Muscle lysates (calculated MW of 53.5kD according to NP_001918.3). Recommended concentration: 0.1-0.3 ug/ml.

Immunohistochemistry (IHC) of anti-DES antibody
Anti-DES / Desmin antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-DES antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-DES antibody
Anti-DES / Desmin antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-DES antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-DES antibody
Antibody (0.2 ug/ml) staining of Human Skeletal Muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-DES antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for DES. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
53,536 Da
NCBI Official Full Name
desmin
NCBI Official Synonym Full Names
desmin
NCBI Official Symbol
NCBI Official Synonym Symbols
CSM1; CSM2; LGMD2R
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NCBI Protein Information
desmin; mutant desmin p.K241E; intermediate filament protein
UniProt Protein Name
Desmin
Protein Family
UniProt Gene Name
UniProt Entry Name
DESM_HUMAN
NCBI Summary for DES
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]
UniProt Comments for DES
desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: intermediate filament; fascia adherens; Z disc; cytosol; neuromuscular junction; sarcolemma

Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding

Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1i; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type; Myopathy, Myofibrillar, 1; Muscular Dystrophy, Limb-girdle, Type 2r
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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