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anti-ABCC5 antibody :: Goat ABCC5 / MRP5 Polyclonal Antibody

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Catalog # MBS241986
Unit / Price
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  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ABCC5 / MRP5, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human ABCC5 / MRP5

Product Synonym Names
Anti-ABCC5 / MRP5 Antibody (N-Terminus) IHC-plus; ABCC5; ABC33; Abcc5a; MOATC; MRP5; PABC11; SMRP; EST277145; MOAT-C; Human ABCC5; MRP5
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
605251
3D Structure
ModBase 3D Structure for O15440
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Bovine, Chicken, Dog, Gorilla, Horse, Human, Monkey, Pig, Rabbit
Predicted Reactivity: Mouse, Rat (at least 90% immunogen sequence identity)
Specificity
Human ABCC5 / MRP5. This antibody is expected to recognize both reported isoforms (NP_005679.2; NP_001018881.1).
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide KDIDIGKEYIIP-C from the N-terminus of human ABCC5 / MRP5 (NP_005679.2; NP_001018881.1).
Immunogen Type
Synthetic peptide
Immunogen
ABCC5 / MRP5 antibody was raised against synthetic peptide KDIDIGKEYIIP-C from the N-terminus of human ABCC5 / MRP5 (NP_005679.2; NP_001018881.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Bovine, Elephant, Panda, Horse, Rabbit, Pig, Turkey, Chicken (100%); Mouse, Rat (92%); Hamster (83%).
Antigen Modification
N-Terminus
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-ABCC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCC5 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABCC5 antibody
ELISA (1:32000), IHC-P (5 ug/ml), WB (1:32000, 0.5 - 1.5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ABCC5 antibody
Anti-ABCC5 / MRP5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ABCC5 antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-ABCC5 antibody
Antibody (0.5 ug/ml) staining of Human Frontal Cortex lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-ABCC5 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ABCC5. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
155,732 Da
NCBI Official Full Name
multidrug resistance-associated protein 5 isoform 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
NCBI Official Symbol
ABCC5  [Similar Products]
NCBI Official Synonym Symbols
MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145
  [Similar Products]
NCBI Protein Information
multidrug resistance-associated protein 5; ATP-binding cassette sub-family C member 5; multi-specific organic anion transporter C; canalicular multispecific organic anion transporter C
UniProt Protein Name
Multidrug resistance-associated protein 5
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11
Protein Family
UniProt Gene Name
ABCC5  [Similar Products]
UniProt Synonym Gene Names
MRP5; MOAT-C  [Similar Products]
UniProt Entry Name
MRP5_HUMAN
NCBI Summary for ABCC5
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCC5
ABCC5: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity; ATP binding

Biological Process: glycosaminoglycan metabolic process; hyaluronan biosynthetic process; transport; carbohydrate metabolic process; pathogenesis; transmembrane transport; hyaluronan metabolic process; organic anion transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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