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anti-ITGA2 antibody :: Rabbit ITGA2 / CD49b Polyclonal Antibody

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Catalog # MBS240182
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

ITGA2 / CD49b, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human ITGA2 / CD49b

Product Synonym Names
Anti-ITGA2 / CD49b Antibody (Extracellular Domain) IHC-plus; ITGA2; Alpha2 integrin; BR; CD49b antigen; CD49B; Integrin alpha2; Integrin Alpha 2; Integrin alpha-2; HPA-5; VLA-2; VLAA2; VLA-2 subunit alpha; Collagen receptor; GPIa; Platelet antigen Br; Platelet glycoprotein GPIa; VLA2 receptor; alpha-2 subunit; Human ITGA2; CD49b
Product Synonym Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
192974
3D Structure
ModBase 3D Structure for P17301
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Dog, Gorilla, Human, Monkey, Pig
Predicted Reactivity: Bovine, Horse, Chicken (at least 90% immunogen sequence identity)
Specificity
Human ITGA2 / CD49b. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
0.7 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from extracellular domain of human ITGA2 / CD49b. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Panda, Pig (100%); Bovine, Elephant, Horse, Chicken, Lizard (94%).
Immunogen Type
Synthetic peptide
Immunogen
ITGA2 / CD49b antibody was raised against synthetic 16 amino acid peptide from extracellular domain of human ITGA2 / CD49b. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Panda, Pig (100%); Bovine, Elephant, Horse, Chicken, Lizard (94%); Opossum, Turkey (88%); Bat, Hamster, Stickleback (81%).
Antigen Modification
Extracellular Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-ITGA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITGA2 antibody
ITGA2 encodes integrin alpha chain 2. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing alpha integrin 2 combines with beta integrin 1 to form a collagen-binding integrin referred to as glycoprotein Ia/IIa when expressed on platelets, and very late (activation) antigen 2 ('VLA-2') when found on T-cells. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Product Categories/Family for anti-ITGA2 antibody
Applications Tested/Suitable for anti-ITGA2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-ITGA2 antibody
IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ITGA2 antibody
Anti-ITGA2 / CD49b antibody IHC of human thymus, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ITGA2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ITGA2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
129,295 Da
NCBI Official Full Name
integrin alpha-2
NCBI Official Synonym Full Names
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
NCBI Official Symbol
ITGA2  [Similar Products]
NCBI Official Synonym Symbols
BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2
  [Similar Products]
NCBI Protein Information
integrin alpha-2; collagen receptor; platelet antigen Br; platelet glycoprotein GPIa; VLA2 receptor, alpha-2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; human platelet alloantigen system 5; very late activation protein 2 receptor, alpha-2 subunit
UniProt Protein Name
Integrin alpha-2
UniProt Synonym Protein Names
CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b
Protein Family
UniProt Gene Name
ITGA2  [Similar Products]
UniProt Synonym Gene Names
CD49B; GPIa  [Similar Products]
UniProt Entry Name
ITA2_HUMAN
NCBI Summary for ITGA2
This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Comments for ITGA2
ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.

Protein type: Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: focal adhesion; cell surface; perinuclear region of cytoplasm; plasma membrane; nerve terminal; nucleus; integrin complex; external side of plasma membrane

Molecular Function: integrin binding; viral receptor activity; collagen binding; protein binding; protein heterodimerization activity; metal ion binding; laminin binding

Biological Process: axon guidance; entry of virus into host cell; response to muscle activity; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; positive regulation of positive chemotaxis; positive regulation of translation; positive regulation of smooth muscle cell proliferation; positive regulation of leukocyte migration; cell-matrix adhesion; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of cell projection organization and biogenesis; mesodermal cell differentiation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to organic cyclic substance; establishment of protein localization; mammary gland development; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; substrate-bound cell migration; integrin-mediated signaling pathway; response to drug; skin morphogenesis; hypotonic response; cell-substrate adhesion; cellular response to hormone stimulus; cell proliferation; detection of mechanical stimulus involved in sensory perception of pain; organ morphogenesis; response to hypoxia; cell adhesion mediated by integrin; blood coagulation; positive regulation of phagocytosis, engulfment; response to amine stimulus; positive regulation of transmission of nerve impulse; positive regulation of inflammatory response

Disease: Bleeding Disorder, Platelet-type, 9
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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