NP_003583.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,679 Da
NCBI Official Full Name
cullin-1
NCBI Official Synonym Full Names
cullin 1
NCBI Protein Information
cullin-1; CUL-1
UniProt Protein Name
Cullin-1
UniProt Synonym Gene Names
UniProt Entry Name
CUL1_HUMAN
UniProt Comments for CUL1
CUL1: a core scaffolding component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. The cullin subunit serves as a rigid scaffold of SCF complexes. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex depends on the neddylation of the cullin subunit. Interacts with multiple F-box proteins in SCF complexes, directing the ubiquitination of many substrates. These F-box proteins and associated substrates include: BTRC and FBXW11 bind CTNNB1 and participate in Wnt signaling; FBXW11 bind phosphorylated NFKBIA; BTRC binds NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2; SKP2 binds phosphorylated p27kip and is involved in regulation of G1/S transition; SKP2 binds ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1; FBXW7 binds cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1; FBXW2 binds GCM1; FBXO32 binds MYOD1; FBXO7 binds BIRC2 and DLGAP5; FBXO33 binds YBX1; and Cyclin F binds CP110. Interacts with CHEK2, mediating its ubiquitination and regulating its function. Belongs to the cullin family.
Protein type: Ubiquitin conjugating system; Cell cycle regulation
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: nucleoplasm; cullin-RING ubiquitin ligase complex; SCF ubiquitin ligase complex; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding
Biological Process: circadian rhythm; protein monoubiquitination; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; viral reproduction; protein ubiquitination; cell proliferation; negative regulation of cell proliferation; organ morphogenesis; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; G2/M transition of mitotic cell cycle; cell cycle arrest; G1/S transition of mitotic cell cycle
Research Articles on CUL1
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Products associated with anti-CUL1 antibody
Pathways associated with anti-CUL1 antibody
Diseases associated with anti-CUL1 antibody
Organs/Tissues associated with anti-CUL1 antibody
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