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anti-CSK antibody :: Rabbit CSK (pS364) Polyclonal Antibody

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Catalog # MBS822339
Unit / Price
  0.03 mL  /  $165 +1 FREE 8GB USB
  0.1 mL  /  $245 +1 FREE 8GB USB
  0.2 mL  /  $350 +1 FREE 8GB USB
anti-CSK antibody
Product Name

CSK (pS364), Polyclonal Antibody

Also Known As

Anti-CSK (pS364) Antibody

Product Synonym Names
Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL
Product Gene Name
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
450
OMIM
124095
3D Structure
ModBase 3D Structure for P41240
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken, Zebrafish
Specificity
Recognizes endogenous levels of CSK (pS364) protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human CSK. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-CSK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CSK antibody
Rabbit polyclonal antibody to CSK (pS364)
Applications Tested/Suitable for anti-CSK antibody
Western Blot (WB)
Application Notes for anti-CSK antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-CSK antibody
anti-CSK antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for CSK. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
50,704 Da
NCBI Official Full Name
tyrosine-protein kinase CSK
NCBI Official Synonym Full Names
c-src tyrosine kinase
NCBI Official Symbol
NCBI Protein Information
tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL
UniProt Protein Name
Tyrosine-protein kinase CSK
UniProt Synonym Protein Names
C-Src kinase; Protein-tyrosine kinase CYL
Protein Family
UniProt Gene Name
UniProt Entry Name
CSK_HUMAN
UniProt Comments for CSK
CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development.

Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; Protein kinase, TK; TK group; Csk family

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; intercellular junction; cytosol; lipid raft

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding; receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of kinase activity; negative regulation of phagocytosis; platelet activation; cell migration; central nervous system development; negative regulation of Golgi to plasma membrane protein transport; T cell receptor signaling pathway; protein amino acid phosphorylation; regulation of cell proliferation; regulation of cytokine production; negative regulation of cell proliferation; positive regulation of MAP kinase activity; T cell costimulation; negative regulation of interleukin-6 production; oligodendrocyte differentiation; morphogenesis of an epithelium; innate immune response; brain development; cell differentiation; negative regulation of bone resorption; blood coagulation; transmembrane receptor protein tyrosine kinase signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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