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anti-ESR1 antibody :: Estrogen Receptor alpha (pY537) Polyclonal Antibody

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Catalog # MBS822018
Unit / Price
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  0.03 mL  /  $165 +1 FREE 8GB USB
  0.1 mL  /  $245 +1 FREE 8GB USB
  0.2 mL  /  $350 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Estrogen Receptor alpha (pY537) (ESR1), Polyclonal Antibody

Popular Item
Full Product Name

Anti-Estrogen Receptor alpha (pY537) Antibody

Product Synonym Names
ESR; NR3A1; Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
gene 615363
3D Structure
ModBase 3D Structure for P03372
Clonality
Polyclonal
Species Reactivity
Human, Mouse, Rat, Bovine, Chicken, Pig
Specificity
Recognizes endogenous levels of Estrogen Receptor alpha (pY537) protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Source
Rabbit
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Estrogen Receptor alpha. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-ESR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ESR1 antibody
Rabbit polyclonal antibody to Estrogen Receptor alpha (pY537)
Applications Tested/Suitable for anti-ESR1 antibody
Western Blot (WB)
Application Notes for anti-ESR1 antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-ESR1 antibody
Western blot analysis of Estrogen Receptor alpha (pY537) expression in HeLa (A), SP20 (B), rat spleen (C) whole cell lysates.
anti-ESR1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for ESR1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,547 Da
NCBI Official Full Name
estrogen receptor isoform 1
NCBI Official Synonym Full Names
estrogen receptor 1
NCBI Official Symbol
NCBI Official Synonym Symbols
ER; ESR; Era; ESRA; ESTRR; NR3A1
  [Similar Products]
NCBI Protein Information
estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1
UniProt Protein Name
Estrogen receptor
UniProt Synonym Protein Names
ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
ESR; NR3A1; ER  [Similar Products]
UniProt Entry Name
ESR1_HUMAN
NCBI Summary for ESR1
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]
UniProt Comments for ESR1
ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: identical protein binding; protein binding; estrogen receptor activity; enzyme binding; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; steroid hormone receptor activity; chromatin binding; transcription factor activity; transcription factor binding; steroid binding

Biological Process: estrogen receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; uterus development; signal transduction; response to estradiol stimulus; regulation of apoptosis; elevation of cytosolic calcium ion concentration; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; antral ovarian follicle growth; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; male gonad development; androgen metabolic process; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of transcription factor activity

Disease: Migraine With Or Without Aura, Susceptibility To, 1; Breast Cancer; Myocardial Infarction, Susceptibility To; Estrogen Resistance
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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