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anti-GSK-3b antibody :: Rabbit GSK-3b Polyclonal Antibody

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Catalog # MBS462236
Unit / Price
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  0.1 mg  /  $245 +1 FREE 8GB USB
Testing Data
Product Name

GSK-3b, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit anti GSK-3beta (CT) Polyclonal antibody

Product Synonym Names
Rabbit anti--GSK-3beta (CT); glycogen synthase kinase 3 beta (GSK3-b)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat, Mouse, Bovine, Chicken
Specificity
This antibody recognizes GSK-3beta protein. It reacts with human, mouse and rat.
Purity/Purification
The Rabbit IgG is purified by Epitope Affinity Purification.
Form/Format
This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer
Concentration
Size: 100 ug/200 ul (lot specific)
Antigen Preparation
A synthetic peptide corresponding to the C-terminus of GSK-3beta protein. This sequence is identical among human, mouse, rat, bovine, dog and chicken species.
Positive Control
Mouse muscle tissue lysate
Cellular Location
Cytoplasmic
Preparation and Storage
The antibodies are stable for 12 months from date of receipt when stored at -20 degree C to -70 degree C. The antibodies can be stored at 2 degree C-8 degree C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles
Other Notes
Small volumes of anti-GSK-3b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GSK-3b antibody
Glycogen Synthase Kinase-3beta (GSK-3beta) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. Growth factor (such as Insulin) binds to its receptor, recruits PKB/AKT kinase to phosphorylate GSK-3beta on Serine 9, which prevents GSK-3beta from phosphorylating glycogen synthase. In contrast, the phosphorylation of tyrosine 216 in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3beta is also involved in Wnt signaling pathway where it forms a complex with axin, beta-catenin and adenomatous polyposis coli (APC) protein, thus the GSK-3beta inhibitor is considered as a potential approach in Alzheimer's Disease (AD) treatment.
Applications Tested/Suitable for anti-GSK-3b antibody
ELISA, Western Blot, Immunohistochemistry
Application Notes for anti-GSK-3b antibody
Western Blot: 0.1-1 ug/ml
ELISA: 0.01-0.1 ug/ml
Immunoprecipitation: 2-5 ug/ml

Testing Data of anti-GSK-3b antibody
anti-GSK-3b antibody Testing Data image
NCBI/Uniprot data below describe general gene information for GSK-3b. It may not necessarily be applicable to this product.
NCBI GI #
Molecular Weight
46 kDa
NCBI Official Full Name
glycogen synthase kinase 3 beta
Product References and Citations for anti-GSK-3b antibody
Alan P. Kozikowski, et al. Highly Potent and Specific GSK-3beta Inhibitors That Block Tau Phosphorylation and Decrease alpha-Synuclein Protein Expression in a Cellular Model of Parkinson's Disease. ChemMedChem, 2006, 1 (2), 256-266.

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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