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anti-TOP3A antibody :: Rabbit Topoisomerase 3 alpha Polyclonal Antibody

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Catalog # MBS8213918
Unit / Price
  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

Topoisomerase 3 alpha (TOP3A), Polyclonal Antibody

Popular Item
Also Known As

Anti-Topoisomerase 3 alpha Antibody

Product Synonym Names
TOP3; DNA topoisomerase 3-alpha; DNA topoisomerase III alpha
Antibody/Peptide Pairs
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
1001
OMIM
601243
3D Structure
ModBase 3D Structure for Q13472
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Bovine, Dog, Zebrafish
Specificity
Recognizes endogenous levels of Topoisomerase 3 alpha protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Topoisomerase 3 alpha. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-TOP3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TOP3A antibody
Rabbit polyclonal antibody to Topoisomerase 3 alpha
Applications Tested/Suitable for anti-TOP3A antibody
Western Blot (WB)
Application Notes for anti-TOP3A antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-TOP3A antibody
Western blot analysis of Topoisomerase 3 alpha expression in A549 (A), MCF7 (B) whole cell lysates.
anti-TOP3A antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for TOP3A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
101,208 Da
NCBI Official Full Name
DNA topoisomerase 3-alpha
NCBI Official Synonym Full Names
topoisomerase (DNA) III alpha
NCBI Official Symbol
TOP3A  [Similar Products]
NCBI Official Synonym Symbols
TOP3; ZGRF7
  [Similar Products]
NCBI Protein Information
DNA topoisomerase 3-alpha
UniProt Protein Name
DNA topoisomerase 3-alpha
UniProt Synonym Protein Names
DNA topoisomerase III alpha
Protein Family
UniProt Gene Name
TOP3A  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
TOP3A_HUMAN
NCBI Summary for TOP3A
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]
UniProt Comments for TOP3A
TOP3A: a DNA topoisomerase. Reduces the number of supercoils in a highly negatively supercoiled DNA. Two alternatively spliced human isoforms have been described.

Protein type: EC 5.99.1.2; Isomerase

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: PML body; chromosome; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; DNA topoisomerase type I activity

Biological Process: meiosis; DNA topological change
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-TOP3A antibody
Organs/Tissues associated with anti-TOP3A antibody
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