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anti-PDE7A antibody :: Rabbit PDE7A Polyclonal Antibody

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Catalog # MBS240106
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

PDE7A, Polyclonal Antibody

Popular Item
Also Known As

Rabbit Polyclonal to Human PDE7A

Product Synonym Names
Anti-PDE7A Antibody (N-Terminus) IHC-plus; PDE7A; PDE7A1; PDE7A2; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; PDE7; HCP1; TM22; Human PDE7A
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
482
OMIM
171885
3D Structure
ModBase 3D Structure for Q13946
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Human, Monkey, Orangutan, Rabbit
Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
Specificity
Human PDE7A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
0.4 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from N-terminus of human PDE7A. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Elephant, Panda, Rabbit, Opossum, Xenopus (100%).
Immunogen Type
Synthetic peptide
Immunogen
PDE7A antibody was raised against synthetic 17 amino acid peptide from N-terminus of human PDE7A. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Elephant, Panda, Rabbit, Opossum, Xenopus (100%); Mouse, Rat, Hamster, Turkey, Lizard (94%); Zebrafish (82%).
Antigen Modification
N-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Other Notes
Small volumes of anti-PDE7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PDE7A antibody
Phosphodiesterase 7A, a cAMP-specific phosphodiesterase, has been shown to affect memory, T-cell functioning and emesis and has been implicated in depression. Two isoforms (PDE7A1 and PDE7A2) which differ at their N-terminal region, have been reported.
Applications Tested/Suitable for anti-PDE7A antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-PDE7A antibody
IHC-P (20 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...

Immunohistochemistry (IHC) of anti-PDE7A antibody
Anti-PDE7A antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-PDE7A antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for PDE7A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
48,828 Da
NCBI Official Full Name
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform c
NCBI Official Synonym Full Names
phosphodiesterase 7A
NCBI Official Symbol
PDE7A  [Similar Products]
NCBI Official Synonym Symbols
HCP1; PDE7
  [Similar Products]
NCBI Protein Information
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; TM22; phosphodiesterase isozyme 7
UniProt Protein Name
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
UniProt Synonym Protein Names
HCP1; TM22
UniProt Gene Name
PDE7A  [Similar Products]
UniProt Entry Name
PDE7A_HUMAN
NCBI Summary for PDE7A
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
UniProt Comments for PDE7A
PDE7A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; EC 3.1.4.53; Phosphodiesterase

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding

Biological Process: cAMP catabolic process; signal transduction
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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