• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-ITPR2 antibody :: Goat ITPR2 / IP3 Receptor Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS242553
Unit / Price
Scan QR to view Datasheet
  0.05 mg  /  $530 +1 FREE 8GB USB
Product Name

ITPR2 / IP3 Receptor, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human ITPR2 / IP3 Receptor

Product Synonym Names
Anti-ITPR2 / IP3 Receptor Antibody (Internal) IHC-plus; ITPR2; IP3R 2; InsP3R2; IP3R2; InsP3R type II; IP3 receptor; InsP3R type 2; IP3 receptor isoform 2; Type 2 InsP3 receptor; Human ITPR2; IP3 Receptor
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
600144
3D Structure
ModBase 3D Structure for Q14571
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Gorilla, Human, Monkey
Predicted Reactivity: Bat, Bovine, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
Specificity
Human ITPR2. No cross-reactivity expected with other types of ITPR.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide C-PIEESNILSPVQD from an internal region of human ITPR2 (NP_002214.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Panda, Bat, Dog, Bovine, Rabbit, Horse, Pig, Opossum (92%); Turkey, Chicken (85%).
Immunogen Type
Synthetic peptide
Immunogen
ITPR2 / IP3 Receptor antibody was raised against synthetic peptide C-PIEESNILSPVQD from an internal region of human ITPR2 (NP_002214.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Panda, Bat, Dog, Bovine, Rabbit, Horse, Pig, Opossum (92%); Turkey, Chicken (85%).
Antigen Modification
Internal
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Other Notes
Small volumes of anti-ITPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ITPR2 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-ITPR2 antibody
ELISA (1:128000), IHC-P (3.75 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-ITPR2 antibody
Anti-ITPR2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
anti-ITPR2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ITPR2 antibody
Anti-ITPR2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
anti-ITPR2 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-ITPR2 antibody
Anti-ITPR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
anti-ITPR2 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for ITPR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,608 Da
NCBI Official Full Name
inositol 1,4,5-trisphosphate receptor type 2
NCBI Official Synonym Full Names
inositol 1,4,5-trisphosphate receptor, type 2
NCBI Official Symbol
ITPR2  [Similar Products]
NCBI Official Synonym Symbols
IP3R2; CFAP48
  [Similar Products]
NCBI Protein Information
inositol 1,4,5-trisphosphate receptor type 2; IP3R 2; insP3R2; IP3 receptor; type 2 InsP3 receptor; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor, type 2; type 2 inositol 1,4,5-trisphosphate receptor
UniProt Protein Name
Inositol 1,4,5-trisphosphate receptor type 2
UniProt Synonym Protein Names
IP3 receptor isoform 2; IP3R 2; InsP3R2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
UniProt Gene Name
ITPR2  [Similar Products]
UniProt Synonym Gene Names
IP3R 2; InsP3R2; Type 2 InsP3 receptor  [Similar Products]
UniProt Entry Name
ITPR2_HUMAN
NCBI Summary for ITPR2
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
UniProt Comments for ITPR2
IP3R2: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Most normal tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in the gastrointestinal tract, hepatocytes and exocrine pancreas. Short isoform Is found in skeletal muscle and heart. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA increases calcium release. Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor. Belongs to the InsP3 receptor family. 2 isoforms of the human protein are produced by alternative splicing. The short isoform is found in skeletal muscle and heart.

Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; plasma membrane; integral to membrane; cell cortex; receptor complex

Molecular Function: calcium ion transmembrane transporter activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity

Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; transport; phospholipase C activation; response to hypoxia; energy reserve metabolic process; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion

Disease: Anhidrosis, Isolated, With Normal Sweat Glands
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-ITPR2 antibody
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000