• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-PDI antibody :: Rabbit PDI Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS247147
Unit / Price
Scan QR to view Datasheet
  0.05 mL  /  $530 +1 FREE 8GB USB
Product Name

PDI, Polyclonal Antibody

Popular Item
Full Product Name

Rabbit Polyclonal to Rat PDI

Product Synonym Names
Anti-PDI Antibody IHC-plus; PDI; Rat PDI
Product Gene Name
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
176790
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Dog, Xenopus, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep
Specificity
Detects ~58 kD protein.
Purity/Purification
Unpurified serum
Form/Format
Antiserum
Target
PDI
Target Species
Rat
Immunogen Description
Rat PDI synthetic peptide conjugated to KLH.
Immunogen Species
PDI antibody was raised against Rat
Immunogen Type
Synthetic peptide - KLH conjugated
Immunogen
PDI antibody was raised against rat PDI synthetic peptide conjugated to KLH.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Other Notes
Small volumes of anti-PDI antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PDI antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-PDI antibody
ICC, IHC-P (1:100 - 1:250), IP, WB (1:4000)

Immunohistochemistry (IHC) of anti-PDI antibody
Anti-PDI antibody IHC of human tonsil, germinal center. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-PDI antibody Immunohistochemistry (IHC) (IHC) image
Western Blot (WB) of anti-PDI antibody
PDI, Rat tissue.
anti-PDI antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for PDI. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,116 Da
NCBI Official Full Name
Protein disulfide-isomerase
NCBI Official Synonym Full Names
prolyl 4-hydroxylase, beta polypeptide
NCBI Official Symbol
NCBI Official Synonym Symbols
DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; ERBA2L; P4Hbeta
  [Similar Products]
NCBI Protein Information
protein disulfide-isomerase; p55; protocollagen hydroxylase; prolyl 4-hydroxylase subunit beta; collagen prolyl 4-hydroxylase beta; thyroid hormone-binding protein p55; glutathione-insulin transhydrogenase; cellular thyroid hormone-binding protein; protein disulfide isomerase-associated 1; protein disulfide isomerase/oxidoreductase; protein disulfide isomerase family A, member 1; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide
UniProt Protein Name
Protein disulfide-isomerase
UniProt Synonym Protein Names
Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55
UniProt Gene Name
UniProt Synonym Gene Names
ERBA2L; PDI; PDIA1; PO4DB; PDI  [Similar Products]
UniProt Entry Name
PDIA1_HUMAN
NCBI Summary for PDI
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
UniProt Comments for PDI
PDIA1: This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Homodimer. Monomers and homotetramers may also occur. Also constitutes the structural subunit of prolyl 4-hydroxylase and of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity. Binds UBQLN1. Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex. Belongs to the protein disulfide isomerase family.

Protein type: EC 5.3.4.1; Nuclear receptor co-regulator; Isomerase; Oxidoreductase; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: focal adhesion; endoplasmic reticulum lumen; endoplasmic reticulum; ER-Golgi intermediate compartment; plasma membrane; extracellular region; melanosome

Molecular Function: protein binding; enzyme binding; procollagen-proline 4-dioxygenase activity; protein heterodimerization activity; endopeptidase activity; protein disulfide isomerase activity

Biological Process: response to reactive oxygen species; extracellular matrix organization and biogenesis; protein folding; cell redox homeostasis; lipoprotein metabolic process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; proteolysis

Disease: Cole-carpenter Syndrome 1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000