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anti-SLC2A1 antibody :: Rabbit GLUT1 Polyclonal Antibody

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Catalog # MBS820435
Unit / Price
  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
Western Blot (WB)
Product Name

GLUT1 (SLC2A1), Polyclonal Antibody

Popular Item
Also Known As

Anti-GLUT1 Antibody

Product Synonym Names
GLUT1; Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter
Antibody/Peptide Pairs
GLUT1 peptide (MBS822980) is used for blocking the activity of GLUT1 antibody (MBS820435)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
492
OMIM
phenotype 614847
3D Structure
ModBase 3D Structure for P11166
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit, Sheep
Specificity
Recognizes endogenous levels of GLUT1 protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GLUT1. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-SLC2A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SLC2A1 antibody
Rabbit polyclonal antibody to GLUT1
Applications Tested/Suitable for anti-SLC2A1 antibody
Western Blot (WB)
Application Notes for anti-SLC2A1 antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-SLC2A1 antibody
Western blot analysis of GLUT1 expression in HepG2 (A), NIH3T3 (B) whole cell lysates.
anti-SLC2A1 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for SLC2A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
54,084 Da
NCBI Official Full Name
solute carrier family 2, facilitated glucose transporter member 1
NCBI Official Synonym Full Names
solute carrier family 2 (facilitated glucose transporter), member 1
NCBI Official Symbol
SLC2A1  [Similar Products]
NCBI Official Synonym Symbols
PED; DYT9; GLUT; DYT17; DYT18; EIG12; GLUT1; HTLVR; GLUT-1; GLUT1DS
  [Similar Products]
NCBI Protein Information
solute carrier family 2, facilitated glucose transporter member 1; hepG2 glucose transporter; receptor for HTLV-1 and HTLV-2; glucose transporter type 1, erythrocyte/brain; human T-cell leukemia virus (I and II) receptor
UniProt Protein Name
Solute carrier family 2, facilitated glucose transporter member 1
UniProt Synonym Protein Names
Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter
Protein Family
UniProt Gene Name
SLC2A1  [Similar Products]
UniProt Synonym Gene Names
GLUT1; GLUT-1  [Similar Products]
UniProt Entry Name
GTR1_HUMAN
NCBI Summary for SLC2A1
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]
UniProt Comments for SLC2A1
GLUT1: an integral membrane protein that plays an important role in the glycolytic pathway by serving as a uniporter for glucose. One of 13 members of the human equilibrative glucose transport protein family. Transports a wide range of aldoses, including both pentoses and hexoses, and dehydroascorbic acid. Shown to transport water against an osmotic gradient. A receptor for the Human T-cell Leukemia virus (HTLV). Plays a role in the constitutive or basal uptake of glucose. Expressed at highest levels in proliferating cells of the early developing embryo, cells forming the blood tissue barriers, in human erythrocytes, astrocytes and in cardiac muscle. GLUT1 and GLUT3 are both essential for normal embryonic development. Is practically the only member of the GLUT family expressed on human red blood cells, where it comprises 10 - 20% of the integral membrane protein content. Several glycolytic proteins including the transporters GLUT1 and GLUT3, as well as multiple enzymes including HK2, PFKL, LDHA, ALDOA, ALDOC, PGK1, ENO1, PKM2, CA9 and PFKFB3 are induced in cancer cells by HIF-1 alpha. Polyps from Peutz-Jeghers patients exhibit up-regulated mTORC1 signaling, HIF-1alpha, and GLUT1 levels. Defects in GLUT1 are the cause of autosomal dominant GLUT1 deficiency syndrome, a blood-brain barrier glucose transport defect characterized by infantile seizures, delayed development, and acquired microcephaly. Defects also cause dystonia type 18, an exercise-induced paroxysmal dystonia/dyskinesia. Cytochalasin B binds to its inner surface, inhibiting its glucose transport activity with an IC50 of 0.44 uM.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p34.2

Cellular Component: cortical actin cytoskeleton; membrane; basolateral plasma membrane; integral to plasma membrane; melanosome; plasma membrane; female pronucleus; intercellular junction; midbody; caveola; cytosol

Molecular Function: identical protein binding; xenobiotic transporter activity; D-glucose transmembrane transporter activity; protein binding; protein self-association; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; kinase binding

Biological Process: cellular response to glucose starvation; vitamin metabolic process; hexose transport; carbohydrate metabolic process; energy reserve metabolic process; L-ascorbic acid metabolic process; xenobiotic transport; protein complex assembly; pathogenesis; glucose transport; response to osmotic stress; transmembrane transport; regulation of insulin secretion; water-soluble vitamin metabolic process

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 12; Dystonia 9; Glut1 Deficiency Syndrome 1; Glut1 Deficiency Syndrome 2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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