NP_001138621.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,121 Da
NCBI Official Full Name
vesicle-associated membrane protein 7 isoform 2
NCBI Official Synonym Full Names
vesicle associated membrane protein 7
NCBI Protein Information
vesicle-associated membrane protein 7
UniProt Protein Name
Vesicle-associated membrane protein 7
UniProt Synonym Protein Names
Synaptobrevin-like protein 1; Tetanus-insensitive VAMP; Ti-VAMP
UniProt Synonym Gene Names
UniProt Entry Name
VAMP7_HUMAN
NCBI Summary for VAMP7
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
UniProt Comments for VAMP7
VAMP7: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28 and Yq12
Cellular Component: apical part of cell; cell junction; cell surface; cytoplasm; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; lamellipodium; late endosome membrane; lysosomal membrane; membrane; neuron projection; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; pseudopodium; secretory granule; secretory granule membrane; SNARE complex; synapse; trans-Golgi network
Molecular Function: protein binding; SNAP receptor activity; SNARE binding; syntaxin binding
Biological Process: calcium ion-dependent exocytosis; endocytosis; endosome to lysosome transport; eosinophil degranulation; ER to Golgi vesicle-mediated transport; Golgi to plasma membrane protein transport; natural killer cell degranulation; neutrophil degranulation; phagocytosis, engulfment; positive regulation of dendrite morphogenesis; post-Golgi vesicle-mediated transport; triacylglycerol transport; vesicle fusion; vesicle fusion with Golgi apparatus; vesicle transport along microtubule; vesicle-mediated transport
Research Articles on VAMP7
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Products associated with VAMP7 antibody pair
Pathways associated with VAMP7 antibody pair
Diseases associated with VAMP7 antibody pair
Organs/Tissues associated with VAMP7 antibody pair
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