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anti-ABCC1 antibody :: Rabbit ABCC1 Polyclonal Antibody

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Catalog # MBS9213738
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Product Name

ABCC1, Polyclonal Antibody

Also Known As

ABCC1 Antibody (C-term)

Product Synonym Names
Multidrug resistance-associated protein 1; ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter; ABCC1; MRP; MRP1
Antibody/Peptide Pairs
ABCC1 peptide (MBS9226191) is used for blocking the activity of ABCC1 antibody (MBS9213738)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
1247-1275
Immunogen Sequence Length
1,541
OMIM
158343
3D Structure
ModBase 3D Structure for P33527
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Bovine, Monkey, Mouse)
Specificity
This ABCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1247-1275 amino acids from the C-terminal region of human ABCC1.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Concentration
Vial Concentration: 2 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCC1 antibody
ABCC1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC gene are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts.
Applications Tested/Suitable for anti-ABCC1 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)
Application Notes for anti-ABCC1 antibody
WB~~1:1000

Western Blot (WB) of anti-ABCC1 antibody
Western blot analysis of ABCC1 antibody (C-term) in Ramos cell line lysates (35ug/lane). ABCC1 (arrow) was detected using the purified Pab.
anti-ABCC1 antibody Western Blot (WB) (WB) image
Flow Cytometry (FC/FACS) of anti-ABCC1 antibody
Flow cytometric analysis of NCI-H292 cells using ABCC1 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-ABCC1 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
NCBI/Uniprot data below describe general gene information for ABCC1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
171591
NCBI Official Full Name
multidrug resistance-associated protein 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family C (CFTR/MRP), member 1
NCBI Official Symbol
ABCC1  [Similar Products]
NCBI Official Synonym Symbols
MRP; ABCC; GS-X; MRP1; ABC29
  [Similar Products]
NCBI Protein Information
multidrug resistance-associated protein 1
UniProt Protein Name
Multidrug resistance-associated protein 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
Protein Family
UniProt Gene Name
ABCC1  [Similar Products]
UniProt Synonym Gene Names
MRP; MRP1; LTC4 transporter  [Similar Products]
UniProt Entry Name
MRP1_HUMAN
NCBI Summary for ABCC1
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
UniProt Comments for ABCC1
ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.

Protein type: Transporter, ABC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATPase activity; ATP binding

Biological Process: response to drug; vitamin metabolic process; transport; cobalamin metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; transmembrane transport; water-soluble vitamin metabolic process
Product References and Citations for anti-ABCC1 antibody
Siedlinski,M., Pharmacogenet. Genomics 19 (9), 675-684 (2009)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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