NP_001166299.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
YTH domain-containing family protein 2 isoform 2
NCBI Official Synonym Full Names
YTH N(6)-methyladenosine RNA binding protein 2
NCBI Protein Information
YTH domain-containing family protein 2
UniProt Protein Name
YTH domain-containing family protein 2
UniProt Synonym Protein Names
CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2
UniProt Synonym Gene Names
UniProt Entry Name
YTHD2_HUMAN
NCBI Summary for YTHDF2
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
UniProt Comments for YTHDF2
YTHDF2: high glucose-regulated protein 8. Two alternatively spliced isoforms have been described.
Protein type: RNA processing; RNA-binding
Chromosomal Location of Human Ortholog: 1p35
Biological Process: regulation of mRNA stability; humoral immune response
Disease: Longevity 1
Product References and Citations for anti-YTHDF2 antibody
Nguyen, T.T., et al. Genes Chromosomes Cancer 45(10):918-932(2006) Cardelli, M., et al. J. Gerontol. A Biol. Sci. Med. Sci. 61(6):547-556(2006) Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005) Stoilov, P., et al. Trends Biochem. Sci. 27(10):495-497(2002) Scanlan, M.J., et al. Int. J. Cancer 83(4):456-464(1999)
Research Articles on YTHDF2
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Products associated with anti-YTHDF2 antibody
Diseases associated with anti-YTHDF2 antibody
Organs/Tissues associated with anti-YTHDF2 antibody
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