• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

anti-YTHDF2 antibody :: Rabbit YTHD2 Polyclonal Antibody

Scan QR to view Datasheet
Catalog # MBS9209250
Unit / Price
  0.08 mL  /  $150 +1 FREE 8GB USB
  0.4 mL  /  $340 +1 FREE 8GB USB
Western Blot (WB)
Product Name

YTHD2 (YTHDF2), Polyclonal Antibody

Popular Item
Also Known As

YTHD2 Antibody (C-term)

Product Synonym Names
YTH domain-containing family protein 2; CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2; YTHDF2; HGRG8
Antibody/Peptide Pairs
YTHD2 peptide (MBS9221661) is used for blocking the activity of YTHD2 antibody (MBS9209250)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
551-579
Immunogen Sequence Length
529
OMIM
610640
3D Structure
ModBase 3D Structure for Q9Y5A9
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Bovine, Monkey, Mouse)
Specificity
This YTHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human YTHD2.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (lot specific)
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Other Accession
Q91YT7, Q4R5D9, Q0VCZ3, NP_001166299.1, NP_001166599.1
Function
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.
Cellular Location
Cytoplasm, P-body
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-YTHDF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-YTHDF2 antibody
YTHDF2 is a member of the YTH (YT521-B homology)
superfamily containing YTH domain. The YTH domain is typical for
the eukaryotes and is particularly abundant in plants. The YTH
domain is usually located in the middle of the protein sequence and
may function in binding to RNA. In addition to a YTH domain, this
protein has a proline rich region which may be involved in signal
transduction. An Alu-rich domain has been identified in one of the
introns of this gene, which is thought to be associated with human
longevity. In addition, reciprocal translocations between this gene
and the Runx1 (AML1) gene on chromosme 21 has been observed in
patients with acute myeloid leukemia. This gene was initially
mapped to chromosome 14, which was later turned out to be a
pseudogene.
Product Categories/Family for anti-YTHDF2 antibody
Applications Tested/Suitable for anti-YTHDF2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-YTHDF2 antibody
WB~~1:1000

Western Blot (WB) of anti-YTHDF2 antibody
YTHD2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the YTHD2 antibody detected the YTHD2 protein (arrow).
anti-YTHDF2 antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for YTHDF2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
Human (Predicted Reactivity: Bovine, Monkey, Mouse)NP_001166599.1; NP_057342.2[Other Products]
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
62334
NCBI Official Full Name
YTH domain-containing family protein 2 isoform 2
NCBI Official Synonym Full Names
YTH N(6)-methyladenosine RNA binding protein 2
NCBI Official Symbol
YTHDF2  [Similar Products]
NCBI Official Synonym Symbols
CAHL; HGRG8; NY-REN-2
  [Similar Products]
NCBI Protein Information
YTH domain-containing family protein 2
UniProt Protein Name
YTH domain-containing family protein 2
UniProt Synonym Protein Names
CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2
UniProt Gene Name
YTHDF2  [Similar Products]
UniProt Synonym Gene Names
HGRG8  [Similar Products]
UniProt Entry Name
YTHD2_HUMAN
NCBI Summary for YTHDF2
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
UniProt Comments for YTHDF2
YTHDF2: high glucose-regulated protein 8. Two alternatively spliced isoforms have been described.

Protein type: RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 1p35

Biological Process: regulation of mRNA stability; humoral immune response

Disease: Longevity 1
Product References and Citations for anti-YTHDF2 antibody
Nguyen, T.T., et al. Genes Chromosomes Cancer 45(10):918-932(2006)
Cardelli, M., et al. J. Gerontol. A Biol. Sci. Med. Sci. 61(6):547-556(2006)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Stoilov, P., et al. Trends Biochem. Sci. 27(10):495-497(2002)
Scanlan, M.J., et al. Int. J. Cancer 83(4):456-464(1999)

Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000