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anti-SLC17A7 antibody :: Goat SLC17A7 / BNPI / VGLUT1 Polyclonal Antibody

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Catalog # MBS243639
Unit / Price
  0.05 mg  /  $530 +1 FREE 8GB USB
Immunohistochemistry (IHC)
Product Name

SLC17A7 / BNPI / VGLUT1, Polyclonal Antibody

Popular Item
Also Known As

Goat Polyclonal to Human SLC17A7 / BNPI / VGLUT1

Product Synonym Names
Anti-SLC17A7 / BNPI / VGLUT1 Antibody IHC-plus; SLC17A7; BNPI; VGLUT1; Human SLC17A7; BNPI; VGLUT1
Product Synonym Gene Name
BNPI; VGLUT1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
560
OMIM
605208
3D Structure
ModBase 3D Structure for Q9P2U7
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Predicted Reactivity: Monkey, Mouse, Rat, Bovine, Pig, Rabbit
Specificity
Human SLC17A7 / VGLUT1.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Concentration
0.5 mg/ml (lot specific)
Target Species
Human
Immunogen Description
Synthetic peptide C-HDQLAGSDDSEMED from an internal region of human SLC17A7 / VGLUT1 (NP_064705.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Elephant (100%); Marmoset, Mouse, Rat, Panda, Bovine, Rabbit, Pig (93%).
Immunogen Type
Synthetic peptide
Immunogen
SLC17A7 / BNPI / VGLUT1 antibody was raised against synthetic peptide C-HDQLAGSDDSEMED from an internal region of human SLC17A7 / VGLUT1 (NP_064705.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Elephant (100%); Marmoset, Mouse, Rat, Panda, Bovine, Rabbit, Pig (93%); Hamster, Dog, Horse (86%).
Usage
Immunohistochemistry: MBS243639 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS243639 was determined to be 3.75ug/ml.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Other Notes
Small volumes of anti-SLC17A7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC17A7 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-SLC17A7 antibody
IHC-P (3.75 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-SLC17A7 antibody
Anti-SLC17A7 / VGLUT1 antibody IHC of human adrenal cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
anti-SLC17A7 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for SLC17A7. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
vesicular glutamate transporter 1
NCBI Official Synonym Full Names
solute carrier family 17 (vesicular glutamate transporter), member 7
NCBI Official Symbol
SLC17A7  [Similar Products]
NCBI Official Synonym Symbols
BNPI; VGLUT1
  [Similar Products]
NCBI Protein Information
vesicular glutamate transporter 1; solute carrier family 17 member 7; brain-specific Na-dependent inorganic phosphate cotransporter; brain-specific Na(+)-dependent inorganic phosphate cotransporter; solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
UniProt Protein Name
Vesicular glutamate transporter 1
UniProt Synonym Protein Names
Brain-specific Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 7
UniProt Gene Name
SLC17A7  [Similar Products]
UniProt Synonym Gene Names
BNPI; VGLUT1; VGluT1  [Similar Products]
UniProt Entry Name
VGLU1_HUMAN
NCBI Summary for SLC17A7
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC17A7
SLC17A7: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Vesicle; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: synaptic vesicle membrane; integral to membrane; presynaptic active zone; plasma membrane; excitatory synapse; cell junction

Molecular Function: sodium:inorganic phosphate symporter activity; sodium-dependent phosphate transmembrane transporter activity; inorganic phosphate transmembrane transporter activity; L-glutamate transmembrane transporter activity

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; L-glutamate import; glutamate secretion; phosphate transport; long-term memory; neurotransmitter secretion; ion transport; regulation of excitatory postsynaptic membrane potential; sequestering of neurotransmitter; transmembrane transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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