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anti-HTR2A antibody :: Rabbit 5-HT2A Polyclonal Antibody

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Catalog # MBS820902
Unit / Price
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  0.03 mL  /  $155 +1 FREE 8GB USB
  0.1 mL  /  $220 +1 FREE 8GB USB
  0.2 mL  /  $295 +1 FREE 8GB USB
anti-HTR2A antibody
Product Name

5-HT2A (HTR2A), Polyclonal Antibody

Full Product Name

Anti-5-HT2A Antibody

Product Synonym Names
HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A
Antibody/Peptide Pairs
5-HT2A peptide (MBS823443) is used for blocking the activity of 5-HT2A antibody (MBS820902)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
182135
3D Structure
ModBase 3D Structure for P28223
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Monkey, Pig
Specificity
Recognizes endogenous levels of 5-HT2A protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human 5-HT2A. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-HTR2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HTR2A antibody
Rabbit polyclonal antibody to 5-HT2A
Applications Tested/Suitable for anti-HTR2A antibody
Western Blot (WB)
Application Notes for anti-HTR2A antibody
WB (1/500 - 1/1000)

Western Blot (WB) of anti-HTR2A antibody
anti-HTR2A antibody Western Blot (WB) (WB) image
NCBI/Uniprot data below describe general gene information for HTR2A. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,940 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2A isoform 1
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
NCBI Official Symbol
HTR2A  [Similar Products]
NCBI Official Synonym Symbols
HTR2; 5-HT2A
  [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor
UniProt Protein Name
5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names
Serotonin receptor 2A
UniProt Gene Name
HTR2A  [Similar Products]
UniProt Synonym Gene Names
HTR2; 5-HT-2; 5-HT-2A  [Similar Products]
UniProt Entry Name
5HT2A_HUMAN
NCBI Summary for HTR2A
This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for HTR2A
5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: cell soma; integral to plasma membrane; axon; cytoplasmic membrane-bound vesicle; plasma membrane; dendritic shaft; caveola; cytosol

Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding

Biological Process: cell death; urinary bladder smooth muscle contraction; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; synaptic transmission; positive regulation of MAP kinase activity; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; aging; regulation of behavior; response to drug; serotonin receptor, phospholipase C activating pathway; regulation of hormone secretion; negative regulation of synaptic transmission, glutamatergic; positive regulation of phosphatidylinositol biosynthetic process; sleep; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation

Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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