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anti-CLTC antibody :: Rabbit Clathrin, Heavy Chain Polyclonal Antibody

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Catalog # MBS610138
Unit / Price
  0.1 mL  /  $540 +1 FREE 8GB USB
Product Name

Clathrin, Heavy Chain (CLTC), Polyclonal Antibody

Popular Item
Also Known As

Clathrin, Heavy Chain

Product Synonym Names
Anti -Clathrin, Heavy Chain
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 17; NC_000017.10 (57697050..57774317). Location: 17q11-qter
OMIM
118955
3D Structure
ModBase 3D Structure for Q00610
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Bovine, Human, Monkey, Mouse, Rat
Specificity
Recognizes endogenous levels of total human Clathrin protein at 190 kD.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA and 50% glycerol.
Immunogen
Synthetic peptide corresponding to residues surrounding Pro1663 of human Clathrin (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-CLTC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CLTC antibody
Clathrin-coated pits, intracellular transport vesicles involved in endocytosis and other membrane trafficking processes, are multi-component units. (1,2). Clathrin, the most abundant protein in these vesicles, is formed of a basic assembly unit called a triskelion composed of three clathrin heavy chains and three clathrin light chains. Together with other coat components such as AP2, epsin and EPS15, triskelia are targeted to appropriate membrane fusion sites, where subsequent invagination, cargo protein uptake and vesicle internalization occurs (3,4).
Product Categories/Family for anti-CLTC antibody
Applications Tested/Suitable for anti-CLTC antibody
ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-CLTC antibody
Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunocytochemistry.
Dilution: Western Blot: 1:1000
Immunofluorescence (IF-IC): 1:400

Western Blot of anti-CLTC antibody
Western Blot of extrats from SHSYSY, Neuro2A, PC12 aNone DetectedCOS cells
anti-CLTC antibody Western Blot (WB) image
Immunofluorescent of anti-CLTC antibody
Confocal immunofluorescent analysis of HeLa cells labeled with MBS610138 (green). Blue pseudocolor = DRAQSTM (fluorescent DNA dye).
anti-CLTC antibody Immunofluorescent image
NCBI/Uniprot data below describe general gene information for CLTC. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
191,615 Da[Similar Products]
NCBI Official Full Name
clathrin heavy chain 1
NCBI Official Synonym Full Names
clathrin, heavy chain (Hc)
NCBI Official Symbol
NCBI Official Synonym Symbols
Hc; CHC; CHC17; CLH-17; CLTCL2; KIAA0034
  [Similar Products]
NCBI Protein Information
clathrin heavy chain 1; OTTHUMP00000165784; OTTHUMP00000165785; clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; clathrin heavy chain on chromosome 17
UniProt Protein Name
Clathrin heavy chain 1
UniProt Synonym Protein Names
Clathrin heavy chain on chromosome 17
Protein Family
UniProt Gene Name
UniProt Synonym Gene Names
CLH17; CLTCL2; KIAA0034  [Similar Products]
UniProt Entry Name
CLH1_HUMAN
NCBI Summary for CLTC
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq]
UniProt Comments for CLTC
CLTC: a major protein component of the cytoplasmic face of coated vesicles and coated pits. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.

Protein type: Vesicle; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q23.1

Cellular Component: clathrin coat of trans-Golgi network vesicle; clathrin coat; focal adhesion; protein complex; clathrin-coated vesicle; intracellular membrane-bound organelle; cytosol; clathrin coat of coated pit; membrane; cytoplasm; melanosome; plasma membrane; trans-Golgi network membrane; spindle; vesicle

Molecular Function: protein binding; double-stranded RNA binding; structural molecule activity; protein kinase binding; clathrin light chain binding

Biological Process: osteoblast differentiation; mitosis; receptor-mediated endocytosis; intracellular protein transport; receptor internalization; transferrin transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; post-Golgi vesicle-mediated transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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