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anti-TPCN2 antibody :: Rabbit TPCN2 Polyclonal Antibody

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Catalog # MBS5400139
Unit / Price
  0.1 mg Biotin  /  $495 +1 FREE 8GB USB
anti-TPCN2 antibody
Product Name

TPCN2, Polyclonal Antibody

Popular Item
Also Known As

TPCN2 Antibody BIOTIN-Conjugated

Product Synonym Names
SHEP10; TPC2; Two pore calcium channel protein 2; Voltage dependent calcium channel protein TPC2 antibody
Antibody/Peptide Pairs
TPCN2 peptide (MBS544601) is used for blocking the activity of TPCN2 antibody (MBS5400139)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Length
752
OMIM
612163
3D Structure
ModBase 3D Structure for Q8NHX9
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Human, Monkey, Mouse, Panda, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.55-0.57 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide corresponding to unique amino acid sequence between TMD4 and TMD5 on TPC2 protein.
Expression
Widely expressed. Expressed at high level in liver and kidney.
Molecular Function
Calcium channel, Ion channel, Voltage-gated channel
Structure
Homodimer (By similarity). Interacts with LRRK2.
Subcellular Location
Lysosome membrane; Multi-pass membrane protein
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-TPCN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TPCN2 antibody
BIOTIN-Conjugated Two pore calcium channel protein 2 Antibody
Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca2+ channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction.
Applications Tested/Suitable for anti-TPCN2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TPCN2 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for TPCN2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85,243 Da
NCBI Official Full Name
two pore calcium channel protein 2
NCBI Official Synonym Full Names
two pore segment channel 2
NCBI Official Symbol
TPCN2  [Similar Products]
NCBI Official Synonym Symbols
TPC2; SHEP10
  [Similar Products]
NCBI Protein Information
two pore calcium channel protein 2
UniProt Protein Name
Two pore calcium channel protein 2
UniProt Synonym Protein Names
Voltage-dependent calcium channel protein TPC2
UniProt Gene Name
TPCN2  [Similar Products]
UniProt Synonym Gene Names
UniProt Entry Name
TPC2_HUMAN
NCBI Summary for TPCN2
This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]
UniProt Comments for TPCN2
TPCN2: Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily.

Protein type: Transporter; Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: endosome membrane; integral to membrane; lysosomal membrane; lysosome; plasma membrane

Molecular Function: identical protein binding; protein binding; protein kinase binding; voltage-gated calcium channel activity

Biological Process: calcium-mediated signaling; cellular calcium ion homeostasis; lysosome organization and biogenesis; regulation of autophagy; release of sequestered calcium ion into cytosol; response to vitamin D; smooth muscle contraction

Disease: Skin/hair/eye Pigmentation, Variation In, 10
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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